A laminin-like adhesive protein concentrated in the synaptic cleft of the neuromuscular junction

A striking example of topographic specificity in synapse formation is the preferential reinnervation of original synaptic sites on denervated muscle fibres by regenerating motor axons. This specificity is mediated by the basal lamina of the synaptic cleft. A glycoprotein, s-laminin, has now been ide...

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Bibliographic Details
Published in:Nature (London) 1989-03, Vol.338 (6212), p.229-234
Main Authors: Hunter, Dale D, Shah, Vandana, Merlie, John P, Sanes, Joshua R
Format: Article
Language:English
Subjects:
Anatomy & physiology
Base Sequence
Basement Membrane - metabolism
Biological and medical sciences
Cell interactions, adhesion
Cloning
Cloning, Molecular
Fundamental and applied biological sciences. Psychology
genes
Immunoblotting
laminin
Laminin - genetics
Laminin - metabolism
Molecular and cellular biology
Molecular Sequence Data
Motor Neurons - metabolism
Muscular system
Nerve Regeneration
Nervous system
Neuromuscular Junction - metabolism
Proteins
Recombinant Proteins - metabolism
skeletal muscle
synapses
Synapses - metabolism
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Summary:A striking example of topographic specificity in synapse formation is the preferential reinnervation of original synaptic sites on denervated muscle fibres by regenerating motor axons. This specificity is mediated by the basal lamina of the synaptic cleft. A glycoprotein, s-laminin, has now been identified that is selectively associated with synaptic basal lamina and is recognized by motoneurons. Molecular cloning reveals that s-laminin is a novel homologue of laminin, a potent promoter of neurite outgrowth.
ISSN:0028-0836
1476-4687
DOI:10.1038/338229a0