Illudinic Acid, a Novel Illudane Sesquiterpene Antibiotic

A novel illudane sesquiterpene antibiotic (1) with activity against methicillin-resistant Staphylococcus aureus (MRSA), has been isolated. Its MIC against MRSA was found to be 16 μg/mL. It also shows L-1210 cytotoxicity with an IC50 of 10−15 μg/mL.

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1997-02, Vol.60 (2), p.188-190
Main Authors: Dufresne, Claude, Young, Katherine, Pelaez, Fernando, Gonzalez Del Val, Antonio, Valentino, Delia, Graham, Amy, Platas, Gonzalo, Bernard, Aurora, Zink, Deborah
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
ANTIBIOTICOS
ANTIBIOTICS
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
ANTIBIOTIQUE
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Applied microbiology
Biological and medical sciences
BOLETALES
CELL CULTURE
CELL LINES
CHAMPIGNON DU SOL
CHEMICAL COMPOSITION
CHEMICAL STRUCTURE
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
CULTIVO DE CELULAS
CULTURE DE CELLULE
CYTOTOXIC COMPOUNDS
DOSAGE EFFECTS
DRUG PLANTS
DRUGS
ESPAGNE
ESPANA
ESPECTROMETRIA
ESTRUCTURA QUIMICA
Fundamental and applied biological sciences. Psychology
HOJARASCA
HONGOS DEL SUELO
L-1210 CELL LINES
LETHAL DOSE
Leukemia L1210 - pathology
LITIERE VEGETALE
MEDICAMENT
MEDICAMENTOS
METHICILLIN
Mice
Microbial Sensitivity Tests
Microbiology
PLANT LITTER
PLANTAS MEDICINALES
PLANTE MEDICINALE
QUERCUS PYRENAICA
RESISTANCE AUX PRODUITS CHIMIQUES
RESISTANCE TO CHEMICALS
RESISTENCIA A PRODUCTOS QUIMICOS
Sesquiterpenes - chemistry
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
SESQUITERPENOIDE
SESQUITERPENOIDS
SESQUITERPENOS
SOIL FUNGI
SPAIN
SPECTRAL ANALYSIS
SPECTROMETRIE
SPECTROMETRY
STAPHYLOCOCCUS AUREUS
Staphylococcus aureus - drug effects
STRUCTURE CHIMIQUE
SUBSTANCE TOXIQUE
SUSTANCIAS TOXICAS
TOXIC SUBSTANCES
TOXICIDAD
TOXICITE
TOXICITY
Tumor Cells, Cultured
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Description
Summary:A novel illudane sesquiterpene antibiotic (1) with activity against methicillin-resistant Staphylococcus aureus (MRSA), has been isolated. Its MIC against MRSA was found to be 16 μg/mL. It also shows L-1210 cytotoxicity with an IC50 of 10−15 μg/mL.
ISSN:0163-3864
1520-6025
DOI:10.1021/np960596x