Role of dopamine D1- and NMDA receptors in regulating neurotensin release in the striatum and nucleus accumbens

Stimulation of dopamine D1-receptors by SKF 82958 increased extracellular neurotensin (NT) levels in the striatum and nucleus accumbens as measured by in vivo microdialysis while blockade of D1-receptors had no effect. Antagonism of NMDA receptors with MK 801 completely prevented the increased NT re...

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Bibliographic Details
Published in:Brain research 1997-02, Vol.748 (1-2), p.241-244
Main Authors: Wagstaff, J D, Gibb, J W, Hanson, G R
Format: Article
Language:English
Subjects:
Animals
Corpus Striatum - metabolism
Dizocilpine Maleate - pharmacology
Excitatory Amino Acid Antagonists - pharmacology
Male
Microdialysis
Neurotensin - metabolism
Nucleus Accumbens - metabolism
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D1 - physiology
Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
Receptors, N-Methyl-D-Aspartate - physiology
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Summary:Stimulation of dopamine D1-receptors by SKF 82958 increased extracellular neurotensin (NT) levels in the striatum and nucleus accumbens as measured by in vivo microdialysis while blockade of D1-receptors had no effect. Antagonism of NMDA receptors with MK 801 completely prevented the increased NT release induced by D1-stimulation in both structures. Tissue content of striatal NT anterior and posterior to the microdialysis probe was oppositely altered by D1-stimulation: increases were observed in the anterior striatum with decreased NT levels in the posterior striatum.
ISSN:0006-8993
DOI:10.1016/S0006-8993(96)01380-7