Sleep EEG and nocturnal secretion of cortisol and growth hormone in male patients with endogenous depression before treatment and after recovery

The authors conducted a sleep-endocrine evaluation among 10 unmedicated male patients with major endogenous depression during their depressive episode and following full clinical remission and drug withdrawal. While abnormally high values for cortisol secretory activity normalized after return to eu...

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Bibliographic Details
Published in:Journal of affective disorders 1989-03, Vol.16 (2), p.189-195
Main Authors: Steiger, A., von Bardeleben, U., Herth, T., Holsboer, F.
Format: Article
Language:English
Subjects:
Adult
Antidepressive Agents - therapeutic use
Circadian Rhythm - drug effects
Cortisol
Depressive Disorder - blood
Depressive Disorder - drug therapy
Electroencephalography
Endogenous depression
Growth hormone
Growth Hormone - blood
Humans
Hydrocortisone - blood
Longitudinal Studies
Male
Middle Aged
Psychological Tests
Sleep EEG
Sleep endocrinology
Sleep Stages - physiology
Sleep, REM - physiology
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Description
Summary:The authors conducted a sleep-endocrine evaluation among 10 unmedicated male patients with major endogenous depression during their depressive episode and following full clinical remission and drug withdrawal. While abnormally high values for cortisol secretory activity normalized after return to euthymia, growth hormone release and characteristic disturbances of EEG sleep remained unchanged. Whether or not neuroendocrine and sleep EEG abnormalities, which are present in remission, are trait markers remains undecided until premorbid sleep-endocrine data are available.
ISSN:0165-0327
DOI:10.1016/0165-0327(89)90073-6