Differential diagnosis of acute HBsAg positive hepatitis using IgM anti-HBc by a rapid, fully automated microparticle enzyme immunoassay

Background/Aims: We determined the diagnostic significance of IgM anti-HBc by a rapid, fully automated microparticle enzyme immunoassay (IMx CORE-M) in acute HBsAg positive hepatitis. Methods: We studied prospectively for at least 6 months 100 patients with acute self-limited hepatitis B (group A) a...

Full description

Saved in:
Bibliographic Details
Published in:Journal of hepatology 1997, Vol.26 (1), p.14-19
Main Authors: Tassopoulos, Nicolaos C., Papaptheodoridis, George V., Kalantzakis, Yiannis, Tzala, Evangelia, Delladetsima, Johanna K., Koutelou, Maria G., Angelopoulou, Paraskevi, Hatzakis, Angelos
Format: Article
Language:English
Subjects:
Acute Disease
Acute hepatitis B
Acute on chronic hepatitis B
Adult
Autoanalysis
Biological and medical sciences
Chronic Disease
Chronic hepatitis B
Diagnosis, Differential
Digestive system
Discriminant Analysis
Female
HBsAg
Hepatitis B - diagnosis
Hepatitis B - immunology
Hepatitis B Core Antigens - immunology
Hepatitis B Surface Antigens - blood
Humans
IgM anti-HBc
Immunoenzyme Techniques
Immunoglobulin M
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Microparticle enzyme immunoassay
Particle Size
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Prospective Studies
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background/Aims: We determined the diagnostic significance of IgM anti-HBc by a rapid, fully automated microparticle enzyme immunoassay (IMx CORE-M) in acute HBsAg positive hepatitis. Methods: We studied prospectively for at least 6 months 100 patients with acute self-limited hepatitis B (group A) and 40 patients with acute hepatitis superimposed on histologically confirmed chronic hepatitis B (group B). On admission, all patients in group A were positive and those in group B were negative for IgM anti-HBc by a commercially available enzyme immunoassay. Results: Based on the assay criteria, the rates of IMx CORE-M ( > 1.2) positive serum samples on admission, 4, 12 and 24 weeks later were: in group A: 100%, 95%, 72%, 44% and in group B: 20%, 27.5%, 17.5%, and 15%, respectively. Misclassification was observed in 20-27.5% of the acute on chronic hepatitis B cases. However, the mean IMx CORE-M index value was found to be significantly higher in group A during the whole follow-up. In particular, on admission the mean IMx CORE-M index value weas 2.504±0.435 (range: 1.508–3.482)_ in group A and 0.747±0.346 (range: 0.062–1.384) in group B ( p
ISSN:0168-8278
1600-0641
DOI:10.1016/S0168-8278(97)80003-7