Role for γ-aminobutyric acid in selective vulnerability in gerbils

We tested the efficacy of various putative neuroprotective agents in the gerbil model of delayed neuronal death. The selective loss of anterior CA1 neurons of the hippocampus 4 days after 5 minutes of bilateral ischemia was complete in greater than 90% of the gerbils examined. We tested 11 agents fo...

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Bibliographic Details
Published in:Stroke (1970) 1989-02, Vol.20 (2), p.281-287
Main Authors: STERNAU, L. L, LUST, W. D, RICCI, A. J, RATCHESON, R
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain Ischemia - drug therapy
Brain Ischemia - metabolism
Cell Survival - drug effects
Disease Models, Animal
Female
gamma-Aminobutyric Acid - physiology
Gerbillinae
Glycogen - metabolism
Hippocampus - metabolism
Hippocampus - pathology
Medical sciences
Nervous system involvement in other diseases. Miscellaneous
Neurology
Neurons - pathology
Time Factors
Tissue Distribution
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Summary:We tested the efficacy of various putative neuroprotective agents in the gerbil model of delayed neuronal death. The selective loss of anterior CA1 neurons of the hippocampus 4 days after 5 minutes of bilateral ischemia was complete in greater than 90% of the gerbils examined. We tested 11 agents for their ability to protect against neuronal loss. Only those agents that were associated with the GABAergic system exhibited protection and only when administered before the ischemic insult. The possibility that delayed neuronal death is the result of a primary defect in inhibitory neurotransmission is considered.
ISSN:0039-2499
1524-4628
DOI:10.1161/01.str.20.2.281