Inhibition of Platelet-Dependent Thrombus Formation by Human Activated Protein C in a Primate Model

The in vivo antithrombotic properties of human plasma activated protein C (APC), a natural anticoagulant enzyme, were investigated in a baboon model of thrombus formation on prosthetic vascular grafts. Infusion of 0.25 to 1.1 mg/kg/h purified, human, APC inhibited blood clotting, as measured by the...

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Bibliographic Details
Published in:Blood 1989-02, Vol.73 (3), p.639-642
Main Authors: Gruber, Andras, Griffin, John H., Harker, Laurence A., Hanson, Stephen R.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood and lymphatic vessels
Blood Coagulation - drug effects
Blood Platelets - physiology
Cardiology. Vascular system
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Enzyme Activation
Fibrinolysis
Graft Occlusion, Vascular
Hemostasis
Medical sciences
Papio
Protein C - pharmacology
Thrombosis - etiology
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Summary:The in vivo antithrombotic properties of human plasma activated protein C (APC), a natural anticoagulant enzyme, were investigated in a baboon model of thrombus formation on prosthetic vascular grafts. Infusion of 0.25 to 1.1 mg/kg/h purified, human, APC inhibited blood clotting, as measured by the activated partial thromboplastin time (APTT), and reduced vascular graft platelet deposition by 40% to 70%, as determined by the real-time scintillation camera imaging of 111ln-labeled platelet deposition. APC infusion also preserved graft patency. Hemostatic plug formation remained normal, as measured by the template bleeding times. These results suggest that APC administration may produce immediate antithrombotic effects under arterial flow conditions.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V73.3.639.639