Effects of Atrial Natriuretic Peptide on Transmural Blood Flow and Reactive Hyperemia in the Presence of Flow-Limiting Coronary Stenosis in the Awake Dog: Evidence for Dilation of the Intramural Vasculature

• Published in: Circulation research 1989-03, Vol.64 (3), p.600-606
• Main Authors: Chu, Alan, Stakely, Adrienne, Lin, Chang-Chyi, Cobb, Frederick R
• Format: Article
• Language: English
• Subjects: Animals; Atrial Natriuretic Factor - pharmacology; Atrial Natriuretic Factor - therapeutic use; Biological and medical sciences; Cardiology. Vascular system; Coronary Circulation - drug effects; Coronary Disease - complications; Coronary Disease - drug therapy; Coronary Disease - physiopathology; Coronary heart disease; Dogs; Drug Evaluation, Preclinical; Heart; Hyperemia - drug therapy; Hyperemia - etiology; Hyperemia - physiopathology; Medical sciences; Microspheres; Time Factors; Vasodilation - drug effects; Wakefulness - drug effects
• ISSN: 0009-7330; 1524-4571
• DOI: 10.1161/01.RES.64.3.600

The effects of atrial natriuretic peptide (ANP) on transmural myocardial blood flow distribution and the reactive hyperemic response in the presence and absence of flow-limiting coronary stenosis were examined in chronically instrumented conscious dogs. Ten-second coronary occlusion without subsequent flow restriction resulted in marked reactive hyperemic responses (Doppler flow probes), mean flow debt repayment was 481±55percent;. When the 10-second coronary occlusions were followed by a 20-second partial restriction that allowed normal preocclusion coronary inflow, the subsequent reactive hyperemia was significantly augmented, mean flow debt repayment was 938±91percent; (p