Triglyceride-rich lipoproteins from apolipoprotein E3/2 subjects with hypertriglyceridemia enhance cholesteryl ester synthesis in human macrophages

The ability of triglyceride (TG)-rich lipoproteins from apolipoprotein (apo) E2 heterozygote, apo E3/2 which is relatively common, to stimulate cholesteryl ester synthesis in human monocyte-derived macrophages was studied to clarify the atherogenicity of apo E3/2. Twenty-three subjects were randomly...

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Bibliographic Details
Published in:Atherosclerosis 1997-02, Vol.129 (1), p.73-77
Main Authors: Saito, Mieko, Eto, Masaaki, Makino, Isao
Format: Article
Language:English
Subjects:
Apolipoprotein E
Apolipoprotein E2
Apolipoprotein E3
Apolipoprotein E3/2
Apolipoproteins E - blood
Apolipoproteins E - genetics
Biological and medical sciences
Cholesterol Esters - biosynthesis
Cholesteryl ester synthesis
Disorders of blood lipids. Hyperlipoproteinemia
Electrophoresis, Polyacrylamide Gel
Female
Genotype
Humans
Hypertriglyceridemia
Hypertriglyceridemia - blood
Hypertriglyceridemia - genetics
Lipoproteins - blood
Lipoproteins, IDL
Lipoproteins, VLDL - blood
Macrophage
Macrophages - metabolism
Male
Medical sciences
Metabolic diseases
Middle Aged
Phenotype
Random Allocation
Triglyceride-rich lipoproteins
Triglycerides - blood
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Summary:The ability of triglyceride (TG)-rich lipoproteins from apolipoprotein (apo) E2 heterozygote, apo E3/2 which is relatively common, to stimulate cholesteryl ester synthesis in human monocyte-derived macrophages was studied to clarify the atherogenicity of apo E3/2. Twenty-three subjects were randomly sampled from our hospitals, and divided into the following 4 groups: 7 apo E3/3 subjects with normolipidemia, 6 apo E3/3 subjects with hypertriglyceridemia (HTG), 5 apo E3/2 subjects with normolipidemia and 5 apo E3/2 subjects with HTG. Plasma levels of TG and total cholesterol (chol) were significantly ( P
ISSN:0021-9150
1879-1484
DOI:10.1016/S0021-9150(96)06026-1