Hyperdynamic circulation in patients with cirrhosis: direct measurement of nitric oxide levels in hepatic and portal veins

Background/Aims: Peripheral vasodilation represents the main vascular dysfunction associated with the hyperdynamic circulation of liver cirrhosis. This study was intended to measure directly regional and systemic levels of nitric oxide, a potent vasorelaxing mediator, in order to assess its role in...

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Bibliographic Details
Published in:Journal of hepatology 1997, Vol.26 (1), p.75-80
Main Authors: Battista, Stefania, Bar, Fabrizio, Mengozzi, Giulio, Zanon, Eugenio, Grosso, Maurizio, Molino, Gianpaolo
Format: Article
Language:English
Subjects:
Aged
Analysis of Variance
Biological and medical sciences
Case-Control Studies
D-Sorbitol clearance
Electron paramagnetic resonance spectroscopy
Electron Spin Resonance Spectroscopy
Female
Gastroenterology. Liver. Pancreas. Abdomen
Hemoglobins - analysis
Hepatic Veins - physiology
Humans
Linear Models
Liver Circulation - physiology
Liver cirrhosis
Liver Cirrhosis - physiopathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Nitric oxide
Nitric Oxide - physiology
Other diseases. Semiology
Portal hypertension
Portal Vein - physiology
Transjugular intrahepatic portosystemic stent shunt
Vasodilation - physiology
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Summary:Background/Aims: Peripheral vasodilation represents the main vascular dysfunction associated with the hyperdynamic circulation of liver cirrhosis. This study was intended to measure directly regional and systemic levels of nitric oxide, a potent vasorelaxing mediator, in order to assess its role in the development of hemodynamic changes of cirrhosis. Methods: We compared nitric oxide levels in the splanchnic and systemic circulation of 25 patients with cirrhosis undergoing transjugular intrahepatic portosystemic stent shunt and in the hepatic vein and peripheral blood of 10 patients without cirrhosis submitted to venous catheterization. Nitric oxide levels were measured through electron paramagnetic resonance spectroscopy as nitrosylhemoglobin complexes. Results: Significantly higher nitric oxide levels were calculated in patients with cirrhosis with respect to controls, both in the peripheral and hepatic veins. In patients with cirrhosis, nitric oxide levels in the portal vein (3.44±2.17, expressed in arbitrary units) were higher than in the systemic circulation (1.89±1.15), but lower than in the hepatic vein (4.75±2.53; p
ISSN:0168-8278
1600-0641
DOI:10.1016/S0168-8278(97)80012-8