The dopaminergic mesencephalic projections to the hippocampal formation in the rat

1. 1. The dopaminergic mesencephalic neurons projecting to the hippocampal formation are distributed in three cell groups: A8 region in the retrorubral field, A9 region in the substantia nigra and A10 region in the ventral tegmental area. 2. 2. Anterograde and retrograde tract-tracing techniques com...

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Bibliographic Details
Published in:Progress in Neuropsychopharmacology & Biological Psychiatry 1997, Vol.21 (1), p.1-22
Main Authors: Gasbarri, Antonella, Sulli, Antonio, Packard, Mark G.
Format: Article
Language:English
Subjects:
Animals
anterograde tracers
Behavioral psychophysiology
Biological and medical sciences
Dopamine - metabolism
dopaminergic neurons
Fundamental and applied biological sciences. Psychology
hippocampal formation
Hippocampus - anatomy & histology
Hippocampus - metabolism
memory
mesencephalon
Mesencephalon - anatomy & histology
Mesencephalon - metabolism
Neurotransmission and behavior
Phaseolus vulgaris-leucoagglutinin (PHA-L)
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
retrograde fluorescent tracers
retrorubral field-A8
substantia nigra-A9
tyrosine hydroxylase (TH)
ventral tegmental area-A10
water maze
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Summary:1. 1. The dopaminergic mesencephalic neurons projecting to the hippocampal formation are distributed in three cell groups: A8 region in the retrorubral field, A9 region in the substantia nigra and A10 region in the ventral tegmental area. 2. 2. Anterograde and retrograde tract-tracing techniques combined with immunohistochemical procedures indicate a topographical organization of mesencephalic dopaminergic projections towards the hippocampal formation. 3. 3. Electrophysiological evidence suggest that dopaminergic mesencephalic neurons could have a regulatory role in suppressing hippocampal excitability. 4. 4. The functional significance of the mesohippocampal dopaminergic system is largely unknown, although it was suggested that this projection could have a role in methamphetamine-produced hypermotility and in modulation of memory processes.
ISSN:0278-5846
1878-4216
DOI:10.1016/S0278-5846(96)00157-1