Abnormal Expression of the p53 Tumor Suppressor Gene in the Conjunctiva of Patients With Pterygium

To determine whether pterygium is a disorder of abnormal growth by examining the expression of the p53 gene in the conjunctiva of patients with pterygium. Immunostaining for abnormal expression of p53 was performed using mouse monoclonal antibody to human p53, pAb 240, on six eyes with primary ptery...

Full description

Saved in:
Bibliographic Details
Published in:American journal of ophthalmology 1997-03, Vol.123 (3), p.404-405
Main Authors: Tan, Donald T.H., Lim, Arthur S.M., Goh, Hak-Su, Smith, Duncan R.
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal
Biological and medical sciences
Conjunctiva - metabolism
Diseases of eyelid, conjunctiva and lacrimal tracts
Epithelium - metabolism
Gene Expression
Genes, p53 - genetics
Humans
Immunoenzyme Techniques
Medical sciences
Ophthalmology
Pterygium - metabolism
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To determine whether pterygium is a disorder of abnormal growth by examining the expression of the p53 gene in the conjunctiva of patients with pterygium. Immunostaining for abnormal expression of p53 was performed using mouse monoclonal antibody to human p53, pAb 240, on six eyes with primary pterygium and two eyes with recurrent pterygium. In three of the eight eyes with pterygium, specimens were positive for abnormal expression in the epithelium of the pterygium and in the superior bulbar conjunctiva. Abnormal p53 expression in the epithelium of primary and recurrent pterygium specimens suggests that pterygium is a growth disorder rather than a degeneration.
ISSN:0002-9394
1879-1891
DOI:10.1016/S0002-9394(14)70141-2