A pre-operative chemoembolization therapy using lipiodol, cisplatin and gelatin sponge for hepatocellular carcinoma

The significance of pre-operative transcatheter arterial chemoembolization therapy using lipiodol, cisplatin and gelatin sponge (Gelfoam) for the prevention of the recurrence of hepatocellular carcinoma (HCC) was evaluated. On the 103 patients who underwent radical operations for HCC with a tumor si...

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Bibliographic Details
Published in:Cancer chemotherapy and pharmacology 1989, Vol.23 Suppl (S1), p.S126-S128
Main Authors: Imaoka, S, Sasaki, Y, Shibata, T, Fujita, M, Kasugai, H, Kojima, J, Ishiguro, S, Ohigashi, H, Ishikawa, O, Fukuda, I
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - therapy
Cisplatin - administration & dosage
Embolization, Therapeutic
Female
Gelatin Sponge, Absorbable - administration & dosage
Humans
Iodized Oil - administration & dosage
Liver Neoplasms - mortality
Liver Neoplasms - pathology
Liver Neoplasms - therapy
Male
Middle Aged
Neoplasm Recurrence, Local
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Summary:The significance of pre-operative transcatheter arterial chemoembolization therapy using lipiodol, cisplatin and gelatin sponge (Gelfoam) for the prevention of the recurrence of hepatocellular carcinoma (HCC) was evaluated. On the 103 patients who underwent radical operations for HCC with a tumor size less than 10 cm, 52 patients received no pre-operative therapy (group C), and 51 patients received pre-operative chemoembolization using lipiodol, a chemotherapeutic agent and Gelfoam. Of these 51 patients, 37 patients received a combination of lipiodol, cisplatin and Gelfoam (group A), while the remaining 14 patients received lipiodol, adriamycin and Gelfoam (group B). The disease-free survival rates after surgery were compared between group A, group B and group C. The 2-year disease-free survival rates in group A, group B and group C were 72%, 46% and 54%, respectively. These rates therefore suggest that pre-operative chemoembolization using lipiodol, cisplatin and Gelfoam is a useful method to prevent the recurrence of HCC after surgery.
ISSN:0344-5704
1432-0843
DOI:10.1007/BF00647258