Variable effects of iodinated contrast media on different rabbit arteries in vitro

• Published in: Urolithiasis 1997, Vol.25 Suppl 1 (S1), p.S21-S23
• Main Authors: Rauch, D, Drescher, P, Knes, J M, Madsen, P O
• Format: Article
• Language: English
• Subjects: Animals; Aorta - drug effects; Aorta - physiology; Arteries - drug effects; Arteries - physiology; Carotid Arteries - drug effects; Carotid Arteries - physiology; Celiac Artery - drug effects; Celiac Artery - physiology; Contrast agents; Contrast Media - pharmacology; Diatrizoate - pharmacology; Glucose - pharmacology; Iliac Artery - drug effects; Iliac Artery - physiology; In Vitro Techniques; Iohexol - pharmacology; Mesenteric Arteries - drug effects; Mesenteric Arteries - physiology; Models, Biological; Osmolar Concentration; Rabbits; Renal Artery - drug effects; Renal Artery - physiology; Vasoconstriction - drug effects; Veins & arteries
• ISSN: 0300-5623; 2194-7228; 1434-0879; 2194-7236
• DOI: 10.1007/BF00942043

Vasoconstriction caused by iodinated contrast media (CM) has been considered specific for the renal artery only. We examined the vascular effect of CM in rabbit carotid, aorta, renal, iliac, mesenteric and celiac arteries and found that other arteries also respond with a contraction to CM. Isolated arterial rings were exposed to diatrizoate (high osmolar CM), iohexol (low osmolar CM) or glucose solution, and the isometric contraction response was expressed as percentage of an initial KCl control contraction. Diatrizoate evoked contractions of 82% (carotid), 63% (aorta), 30% (renal), 24% (iliac), 28% (mesenteric) and 18% (celiac), respectively. Iohexol caused contractions of 31% (carotid), 24% (aorta), 15% (renal) and 14% (iliac), whereas the mesenteric and celiac arteries were relaxed by iohexol. A high osmolar glucose solution elicited contractions of 78%, 77%, 11%, 27%, 3% and 5%, respectively, in the arteries. CM have contraction potency in arterial vasculature other than the renal artery.