The human transcriptional adaptor genes TADA2L and GCN5L2 colocalize to chromosome 17q12-q21 and display a similar tissue expression pattern

The chromosomal locations and the tissue expression patterns of the human transcriptional adaptors TADA2L and GCN5L2 have been determined. Northern blot analysis across a range of human tissues revealed that both the TADA2L and the GCN5L2 mRNAs are expressed to varying degrees in all tissue types. F...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 1997-03, Vol.40 (3), p.497-500
Main Authors: CARTER, K. C, WANG, L, SHELL, B. K, ZAMIR, I, BERGER, S. L, MOORE, P. A
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing
Biological and medical sciences
Cell Cycle Proteins
Chromosome Mapping
Chromosomes, Human, Pair 17
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Genes. Genome
Histone Acetyltransferases
Humans
In Situ Hybridization
Molecular and cellular biology
Molecular genetics
Organ Specificity
p300-CBP Transcription Factors
Trans-Activators - genetics
Transcription Factors - genetics
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Summary:The chromosomal locations and the tissue expression patterns of the human transcriptional adaptors TADA2L and GCN5L2 have been determined. Northern blot analysis across a range of human tissues revealed that both the TADA2L and the GCN5L2 mRNAs are expressed to varying degrees in all tissue types. Furthermore, in most tissue types, the genes are expressed at relatively similar levels, suggesting coordinated regulation of TADA2L and GCN5L2 transcription. Chromosomal mapping by fluorescence in situ hybridization indicated that these genes reside near each other on chromosome 17; TADA2L mapped within bands 17q12-q21, while GCN5L2 mapped distally within band 17q21.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1996.4605