Pluripotent hemopoietic stem cells are c-kit<low

Pluripotent hemopoietic stem cells (P-HSCs) were thought to be c-kit + , but recent reports indicate that they are c-kit low . In the present report, we provide evidence using Ly5 congenic mice that P-HSCs are c-kit

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1997-03, Vol.94 (6), p.2513-2517
Main Authors: Doi, H, Inaba, M, Yamamoto, Y, Taketani, S, Mori, S I, Sugihara, A, Ogata, H, Toki, J, Hisha, H, Inaba, K, Sogo, S, Adachi, M, Matsuda, T, Good, R A, Ikehara, S
Format: Article
Language:English
Subjects:
Animals
Biological Sciences
Bone Marrow Cells
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells - immunology
Mice
Mice, Inbred C57BL
Polymerase Chain Reaction
Proto-Oncogene Proteins c-kit - analysis
Proto-Oncogene Proteins c-kit - biosynthesis
Proto-Oncogene Proteins c-kit - genetics
Spleen - cytology
Thymus Gland - cytology
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Description
Summary:Pluripotent hemopoietic stem cells (P-HSCs) were thought to be c-kit + , but recent reports indicate that they are c-kit low . In the present report, we provide evidence using Ly5 congenic mice that P-HSCs are c-kit
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.94.6.2513