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Interpreting DNA Mixtures

The interpretation of mixed DNA stains is explained in the context of likelihood ratios. The probabilities for the mixed-stain profile are evaluated under alternative explanations that specify the numbers of contributors and the profiles of any known contributors. Interpretations based simply on the...

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Published in:	Journal of forensic sciences 1997-03, Vol.42 (2), p.213-222
Main Authors:	Weir, BS, Triggs, CM, Starling, L, Stowell, LI, Walsh, KAJ, Buckleton, J
Format:	Article
Language:	English
Subjects:	Alleles Coloring Agents - analysis Data Interpretation, Statistical Deoxyribonucleic acid DNA DNA - analysis Forensic Medicine - methods Forensic sciences Genetics Humans Likelihood Functions
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creator	Weir, BS Triggs, CM Starling, L Stowell, LI Walsh, KAJ Buckleton, J
description	The interpretation of mixed DNA stains is explained in the context of likelihood ratios. The probabilities for the mixed-stain profile are evaluated under alternative explanations that specify the numbers of contributors and the profiles of any known contributors. Interpretations based simply on the frequencies with which random members of a population would not be excluded from a mixed-stain profile do not make use of all the information, and may overstate the strength of the evidence against included people. The effects of the numbers of contributors depends on whether all the alleles at a locus are present in the mixed stain. A general equation is given to allow likelihood ratios to be calculated, and includes the "2p" modification suggested by the 1996 NRC report. This modification is not always conservative. A computer program to perform calculations is available.
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subjects	Alleles Coloring Agents - analysis Data Interpretation, Statistical Deoxyribonucleic acid DNA DNA - analysis Forensic Medicine - methods Forensic sciences Genetics Humans Likelihood Functions
title	Interpreting DNA Mixtures
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