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De novo and apparent de novo hepatitis B virus infection after liver transplantation
Background/Aims: The aim of this study was to clarify the aetiology of apparent de novo HBV infection after liver transplantation. Methods: Twenty out of 570 HBsAg negative patients (3.5%) became HBsAg positive after transplantation and were studied. Donor and recipient sera were retrospectively tes...
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Published in: | Journal of hepatology 1997-03, Vol.26 (3), p.517-526 |
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container_title | Journal of hepatology |
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creator | Roche, Bruno Samuel, Didier Gigou, Michele Feray, Cyrille Virot, Veronique Schmets, Laurent David, Marie Françoise Arulnaden, Jean Louis Bismuth, Alain Reynes, Michel Bismuth, Henri |
description | Background/Aims: The aim of this study was to clarify the aetiology of apparent
de novo HBV infection after liver transplantation.
Methods: Twenty out of 570 HBsAg negative patients (3.5%) became HBsAg positive after transplantation and were studied. Donor and recipient sera were retrospectively tested for HBsAg, anti-HBs, anti-HBc, and HBV DNA by PCR. Donor and recipient livers were tested for HBV DNA by PCR on paraffin-embedded tissue.
Results: Group 1: HBV infection of donor origin (eight patients): one donor serum was HBsAg positive, three were serum HBV DNA positive, four were liver HBV DNA positive. Group 2: reactivation of latent HBV infection (eight patients) with detection of HBV DNA in pretransplant serum (seven patients) or in native liver (one patient): three were anti-HBs positive, two anti-HBc positive, and three with fulminant hepatitis had no serological HBV markers. Group 3: undetermined origin (four patients) defined by absence of HBV DNA in pretransplant donor and/or recipient sera and liver; however, acquired infection was suspected from two anti-HBs and anti-HBc positive donors. Two patients became HBsAg negative, and five HBV DNA negative. One died from HBV-cirrhosis and two were retransplanted. In the others, the last histology showed cirrhosis (three), chronic hepatitis (nine), acute hepatitis (one), and non-specific change (four patients).
Conclusions: The prevalence of
de novo HBV infection in liver transplant patients was 3.5%; the aetiology was determined in
16
20
patients: from the donor in eight, and from the recipient in eight. One should be cautions when donors or recipients are anti-HBc or both anti-HBs and anti-HBc positive. |
doi_str_mv | 10.1016/S0168-8278(97)80416-3 |
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fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78882442</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0168827897804163</els_id><sourcerecordid>78882442</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-46307c36acd4089df9418db0ca0fba256a32a9f86332e1b468d7f2c7ced719eb3</originalsourceid><addsrcrecordid>eNqFkE1P3DAQhq2qFSy0PwHJB1TBIWDHjj9OFdAPkJA4QM-WY4-FUTZJbe9K_ff1stFeexlLfp8Zjx-Ezii5ooSK6-daVKNaqS60vFSEU9GwD2hFBSENEZx-RKsDcoxOcn4jhDCi-RE60kR2olMr9PId8DhtJ2xHj-082wRjwX65fIXZllhixrd4G9Mm4zgGcCVOI7ahQMJD3NZakh3zPNix2F32GX0KdsjwZTlP0e-fP17u7pvHp18PdzePjWNKl4YLRqRjwjrPidI-aE6V74mzJPS27YRlrdVBCcZaoD0XysvQOunAS6qhZ6fo637unKY_G8jFrGN2MNRFYNpkI5VSLedtBbs96NKUc4Jg5hTXNv01lJidTfNu0-xUGS3Nu03Dat_Z8sCmX4M_dC36an6-5DY7O4SqwcV8wNpOK612Y77tMagythGSyS7CWP8RU7Vp_BT_s8g_NieR6A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78882442</pqid></control><display><type>article</type><title>De novo and apparent de novo hepatitis B virus infection after liver transplantation</title><source>Elsevier</source><creator>Roche, Bruno ; Samuel, Didier ; Gigou, Michele ; Feray, Cyrille ; Virot, Veronique ; Schmets, Laurent ; David, Marie Françoise ; Arulnaden, Jean Louis ; Bismuth, Alain ; Reynes, Michel ; Bismuth, Henri</creator><creatorcontrib>Roche, Bruno ; Samuel, Didier ; Gigou, Michele ; Feray, Cyrille ; Virot, Veronique ; Schmets, Laurent ; David, Marie Françoise ; Arulnaden, Jean Louis ; Bismuth, Alain ; Reynes, Michel ; Bismuth, Henri</creatorcontrib><description>Background/Aims: The aim of this study was to clarify the aetiology of apparent
de novo HBV infection after liver transplantation.
Methods: Twenty out of 570 HBsAg negative patients (3.5%) became HBsAg positive after transplantation and were studied. Donor and recipient sera were retrospectively tested for HBsAg, anti-HBs, anti-HBc, and HBV DNA by PCR. Donor and recipient livers were tested for HBV DNA by PCR on paraffin-embedded tissue.
Results: Group 1: HBV infection of donor origin (eight patients): one donor serum was HBsAg positive, three were serum HBV DNA positive, four were liver HBV DNA positive. Group 2: reactivation of latent HBV infection (eight patients) with detection of HBV DNA in pretransplant serum (seven patients) or in native liver (one patient): three were anti-HBs positive, two anti-HBc positive, and three with fulminant hepatitis had no serological HBV markers. Group 3: undetermined origin (four patients) defined by absence of HBV DNA in pretransplant donor and/or recipient sera and liver; however, acquired infection was suspected from two anti-HBs and anti-HBc positive donors. Two patients became HBsAg negative, and five HBV DNA negative. One died from HBV-cirrhosis and two were retransplanted. In the others, the last histology showed cirrhosis (three), chronic hepatitis (nine), acute hepatitis (one), and non-specific change (four patients).
Conclusions: The prevalence of
de novo HBV infection in liver transplant patients was 3.5%; the aetiology was determined in
16
20
patients: from the donor in eight, and from the recipient in eight. One should be cautions when donors or recipients are anti-HBc or both anti-HBs and anti-HBc positive.</description><identifier>ISSN: 0168-8278</identifier><identifier>EISSN: 1600-0641</identifier><identifier>DOI: 10.1016/S0168-8278(97)80416-3</identifier><identifier>PMID: 9075658</identifier><identifier>CODEN: JOHEEC</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Adult ; Antiviral Agents - therapeutic use ; Biological and medical sciences ; Biomarkers ; DNA, Viral - analysis ; Female ; Follow-Up Studies ; Graft Rejection - immunology ; Graft Rejection - pathology ; Graft Rejection - therapy ; Hepatitis B ; Hepatitis B - epidemiology ; Hepatitis B - etiology ; Hepatitis B - transmission ; Hepatitis B Antibodies - analysis ; Hepatitis B Surface Antigens - immunology ; Hepatitis B virus - genetics ; Hepatitis B virus - immunology ; Human viral diseases ; Humans ; Immunohistochemistry ; Infectious diseases ; Liver transplantation ; Liver Transplantation - adverse effects ; Male ; Medical sciences ; Middle Aged ; Polymerase Chain Reaction ; Prevalence ; Recurrence ; Reoperation ; Retrospective Studies ; Survival Rate ; Transplantation, Homologous - pathology ; Treatment Outcome ; Viral diseases ; Viral hepatitis</subject><ispartof>Journal of hepatology, 1997-03, Vol.26 (3), p.517-526</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-46307c36acd4089df9418db0ca0fba256a32a9f86332e1b468d7f2c7ced719eb3</citedby><cites>FETCH-LOGICAL-c389t-46307c36acd4089df9418db0ca0fba256a32a9f86332e1b468d7f2c7ced719eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2598983$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9075658$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roche, Bruno</creatorcontrib><creatorcontrib>Samuel, Didier</creatorcontrib><creatorcontrib>Gigou, Michele</creatorcontrib><creatorcontrib>Feray, Cyrille</creatorcontrib><creatorcontrib>Virot, Veronique</creatorcontrib><creatorcontrib>Schmets, Laurent</creatorcontrib><creatorcontrib>David, Marie Françoise</creatorcontrib><creatorcontrib>Arulnaden, Jean Louis</creatorcontrib><creatorcontrib>Bismuth, Alain</creatorcontrib><creatorcontrib>Reynes, Michel</creatorcontrib><creatorcontrib>Bismuth, Henri</creatorcontrib><title>De novo and apparent de novo hepatitis B virus infection after liver transplantation</title><title>Journal of hepatology</title><addtitle>J Hepatol</addtitle><description>Background/Aims: The aim of this study was to clarify the aetiology of apparent
de novo HBV infection after liver transplantation.
Methods: Twenty out of 570 HBsAg negative patients (3.5%) became HBsAg positive after transplantation and were studied. Donor and recipient sera were retrospectively tested for HBsAg, anti-HBs, anti-HBc, and HBV DNA by PCR. Donor and recipient livers were tested for HBV DNA by PCR on paraffin-embedded tissue.
Results: Group 1: HBV infection of donor origin (eight patients): one donor serum was HBsAg positive, three were serum HBV DNA positive, four were liver HBV DNA positive. Group 2: reactivation of latent HBV infection (eight patients) with detection of HBV DNA in pretransplant serum (seven patients) or in native liver (one patient): three were anti-HBs positive, two anti-HBc positive, and three with fulminant hepatitis had no serological HBV markers. Group 3: undetermined origin (four patients) defined by absence of HBV DNA in pretransplant donor and/or recipient sera and liver; however, acquired infection was suspected from two anti-HBs and anti-HBc positive donors. Two patients became HBsAg negative, and five HBV DNA negative. One died from HBV-cirrhosis and two were retransplanted. In the others, the last histology showed cirrhosis (three), chronic hepatitis (nine), acute hepatitis (one), and non-specific change (four patients).
Conclusions: The prevalence of
de novo HBV infection in liver transplant patients was 3.5%; the aetiology was determined in
16
20
patients: from the donor in eight, and from the recipient in eight. One should be cautions when donors or recipients are anti-HBc or both anti-HBs and anti-HBc positive.</description><subject>Adult</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>DNA, Viral - analysis</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Graft Rejection - immunology</subject><subject>Graft Rejection - pathology</subject><subject>Graft Rejection - therapy</subject><subject>Hepatitis B</subject><subject>Hepatitis B - epidemiology</subject><subject>Hepatitis B - etiology</subject><subject>Hepatitis B - transmission</subject><subject>Hepatitis B Antibodies - analysis</subject><subject>Hepatitis B Surface Antigens - immunology</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B virus - immunology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Infectious diseases</subject><subject>Liver transplantation</subject><subject>Liver Transplantation - adverse effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polymerase Chain Reaction</subject><subject>Prevalence</subject><subject>Recurrence</subject><subject>Reoperation</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>Transplantation, Homologous - pathology</subject><subject>Treatment Outcome</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><issn>0168-8278</issn><issn>1600-0641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFkE1P3DAQhq2qFSy0PwHJB1TBIWDHjj9OFdAPkJA4QM-WY4-FUTZJbe9K_ff1stFeexlLfp8Zjx-Ezii5ooSK6-daVKNaqS60vFSEU9GwD2hFBSENEZx-RKsDcoxOcn4jhDCi-RE60kR2olMr9PId8DhtJ2xHj-082wRjwX65fIXZllhixrd4G9Mm4zgGcCVOI7ahQMJD3NZakh3zPNix2F32GX0KdsjwZTlP0e-fP17u7pvHp18PdzePjWNKl4YLRqRjwjrPidI-aE6V74mzJPS27YRlrdVBCcZaoD0XysvQOunAS6qhZ6fo637unKY_G8jFrGN2MNRFYNpkI5VSLedtBbs96NKUc4Jg5hTXNv01lJidTfNu0-xUGS3Nu03Dat_Z8sCmX4M_dC36an6-5DY7O4SqwcV8wNpOK612Y77tMagythGSyS7CWP8RU7Vp_BT_s8g_NieR6A</recordid><startdate>19970301</startdate><enddate>19970301</enddate><creator>Roche, Bruno</creator><creator>Samuel, Didier</creator><creator>Gigou, Michele</creator><creator>Feray, Cyrille</creator><creator>Virot, Veronique</creator><creator>Schmets, Laurent</creator><creator>David, Marie Françoise</creator><creator>Arulnaden, Jean Louis</creator><creator>Bismuth, Alain</creator><creator>Reynes, Michel</creator><creator>Bismuth, Henri</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970301</creationdate><title>De novo and apparent de novo hepatitis B virus infection after liver transplantation</title><author>Roche, Bruno ; Samuel, Didier ; Gigou, Michele ; Feray, Cyrille ; Virot, Veronique ; Schmets, Laurent ; David, Marie Françoise ; Arulnaden, Jean Louis ; Bismuth, Alain ; Reynes, Michel ; Bismuth, Henri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-46307c36acd4089df9418db0ca0fba256a32a9f86332e1b468d7f2c7ced719eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>DNA, Viral - analysis</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Graft Rejection - immunology</topic><topic>Graft Rejection - pathology</topic><topic>Graft Rejection - therapy</topic><topic>Hepatitis B</topic><topic>Hepatitis B - epidemiology</topic><topic>Hepatitis B - etiology</topic><topic>Hepatitis B - transmission</topic><topic>Hepatitis B Antibodies - analysis</topic><topic>Hepatitis B Surface Antigens - immunology</topic><topic>Hepatitis B virus - genetics</topic><topic>Hepatitis B virus - immunology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Infectious diseases</topic><topic>Liver transplantation</topic><topic>Liver Transplantation - adverse effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Polymerase Chain Reaction</topic><topic>Prevalence</topic><topic>Recurrence</topic><topic>Reoperation</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><topic>Transplantation, Homologous - pathology</topic><topic>Treatment Outcome</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roche, Bruno</creatorcontrib><creatorcontrib>Samuel, Didier</creatorcontrib><creatorcontrib>Gigou, Michele</creatorcontrib><creatorcontrib>Feray, Cyrille</creatorcontrib><creatorcontrib>Virot, Veronique</creatorcontrib><creatorcontrib>Schmets, Laurent</creatorcontrib><creatorcontrib>David, Marie Françoise</creatorcontrib><creatorcontrib>Arulnaden, Jean Louis</creatorcontrib><creatorcontrib>Bismuth, Alain</creatorcontrib><creatorcontrib>Reynes, Michel</creatorcontrib><creatorcontrib>Bismuth, Henri</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roche, Bruno</au><au>Samuel, Didier</au><au>Gigou, Michele</au><au>Feray, Cyrille</au><au>Virot, Veronique</au><au>Schmets, Laurent</au><au>David, Marie Françoise</au><au>Arulnaden, Jean Louis</au><au>Bismuth, Alain</au><au>Reynes, Michel</au><au>Bismuth, Henri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>De novo and apparent de novo hepatitis B virus infection after liver transplantation</atitle><jtitle>Journal of hepatology</jtitle><addtitle>J Hepatol</addtitle><date>1997-03-01</date><risdate>1997</risdate><volume>26</volume><issue>3</issue><spage>517</spage><epage>526</epage><pages>517-526</pages><issn>0168-8278</issn><eissn>1600-0641</eissn><coden>JOHEEC</coden><abstract>Background/Aims: The aim of this study was to clarify the aetiology of apparent
de novo HBV infection after liver transplantation.
Methods: Twenty out of 570 HBsAg negative patients (3.5%) became HBsAg positive after transplantation and were studied. Donor and recipient sera were retrospectively tested for HBsAg, anti-HBs, anti-HBc, and HBV DNA by PCR. Donor and recipient livers were tested for HBV DNA by PCR on paraffin-embedded tissue.
Results: Group 1: HBV infection of donor origin (eight patients): one donor serum was HBsAg positive, three were serum HBV DNA positive, four were liver HBV DNA positive. Group 2: reactivation of latent HBV infection (eight patients) with detection of HBV DNA in pretransplant serum (seven patients) or in native liver (one patient): three were anti-HBs positive, two anti-HBc positive, and three with fulminant hepatitis had no serological HBV markers. Group 3: undetermined origin (four patients) defined by absence of HBV DNA in pretransplant donor and/or recipient sera and liver; however, acquired infection was suspected from two anti-HBs and anti-HBc positive donors. Two patients became HBsAg negative, and five HBV DNA negative. One died from HBV-cirrhosis and two were retransplanted. In the others, the last histology showed cirrhosis (three), chronic hepatitis (nine), acute hepatitis (one), and non-specific change (four patients).
Conclusions: The prevalence of
de novo HBV infection in liver transplant patients was 3.5%; the aetiology was determined in
16
20
patients: from the donor in eight, and from the recipient in eight. One should be cautions when donors or recipients are anti-HBc or both anti-HBs and anti-HBc positive.</abstract><cop>Oxford</cop><pub>Elsevier B.V</pub><pmid>9075658</pmid><doi>10.1016/S0168-8278(97)80416-3</doi><tpages>10</tpages></addata></record> |
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subjects | Adult Antiviral Agents - therapeutic use Biological and medical sciences Biomarkers DNA, Viral - analysis Female Follow-Up Studies Graft Rejection - immunology Graft Rejection - pathology Graft Rejection - therapy Hepatitis B Hepatitis B - epidemiology Hepatitis B - etiology Hepatitis B - transmission Hepatitis B Antibodies - analysis Hepatitis B Surface Antigens - immunology Hepatitis B virus - genetics Hepatitis B virus - immunology Human viral diseases Humans Immunohistochemistry Infectious diseases Liver transplantation Liver Transplantation - adverse effects Male Medical sciences Middle Aged Polymerase Chain Reaction Prevalence Recurrence Reoperation Retrospective Studies Survival Rate Transplantation, Homologous - pathology Treatment Outcome Viral diseases Viral hepatitis |
title | De novo and apparent de novo hepatitis B virus infection after liver transplantation |
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