Significant DQw1 association in achalasia

Achalasia is a neuromuscular disorder of the esophagus with unknown etiology. There have been suggestions that this disorder is immunologically mediated. To examine this possibility, HLA phenotyping was prospectively performed on 40 patients with documented achalasia (24 Caucasian, 16 blacks). Resul...

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Bibliographic Details
Published in:Digestive diseases and sciences 1989-03, Vol.34 (3), p.349-352
Main Authors: WONG, R. K. H, MAYDONOVITCH, C. L, METZ, S. J, BAKER, J. R. JR
Format: Article
Language:English
Subjects:
Adult
African Continental Ancestry Group
Biological and medical sciences
Esophageal Achalasia - genetics
Esophageal Achalasia - immunology
Esophagus
European Continental Ancestry Group
Gastroenterology. Liver. Pancreas. Abdomen
HLA-DQ Antigens - analysis
HLA-DQ Antigens - genetics
HLA-DR Antigens - analysis
HLA-DR Antigens - genetics
Humans
Medical sciences
Other diseases. Semiology
Prospective Studies
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Summary:Achalasia is a neuromuscular disorder of the esophagus with unknown etiology. There have been suggestions that this disorder is immunologically mediated. To examine this possibility, HLA phenotyping was prospectively performed on 40 patients with documented achalasia (24 Caucasian, 16 blacks). Results showed a positive association for the class II HLA antigen, DQw1, with 83% of Caucasians (P less than 0.02) and 86% of blacks having the antigen (NS). The relative risk for developing achalasia with the presence of DQw1 was 4.2 in Caucasians and 3.6 in blacks. A negative correlation for the DRw53 antigen was noted in Caucasian patients with a relative risk of 0.23. These results indicate an immunogenetic association for achalasia and provide insight into the pathogenesis of this disorder.
ISSN:0163-2116
1573-2568
DOI:10.1007/BF01536254