Lipopolysaccharide pre-treatment induces resistance against subsequent focal cerebral ischemic damage in spontaneously hypertensive rats

Ischemic tolerance was induced in spontaneously hypertensive rats (SHR) by injection of a single dose of lipopolysaccharide (LPS) (0.9 mg/kg, i.v.) 1–7 days prior to permanent middle cerebral artery occlusion (MCAO). Infarct volume, evaluated 24 h after MCAO, was significantly reduced by LPS adminis...

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Bibliographic Details
Published in:Brain research 1997-02, Vol.748 (1), p.267-270
Main Authors: Tasaki, Kaoru, Ruetzler, Christl A, Ohtsuki, Toshiho, Martin, David, Nawashiro, Hiroshi, Hallenbeck, John M
Format: Article
Language:English
Subjects:
Animals
Brain Ischemia - pathology
Brain Ischemia - prevention & control
Carrier Proteins - pharmacology
Cerebral Infarction - pathology
Cerebral ischemia
Endotoxin
Hypertension - physiopathology
Lipopolysaccharide
Lipopolysaccharides - pharmacology
Male
Rat
Rats
Rats, Inbred SHR - physiology
Receptors, Tumor Necrosis Factor
Receptors, Tumor Necrosis Factor, Type I
Tolerance
Tumor Necrosis Factor Decoy Receptors
Tumor necrosis factor α
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Summary:Ischemic tolerance was induced in spontaneously hypertensive rats (SHR) by injection of a single dose of lipopolysaccharide (LPS) (0.9 mg/kg, i.v.) 1–7 days prior to permanent middle cerebral artery occlusion (MCAO). Infarct volume, evaluated 24 h after MCAO, was significantly reduced by LPS administration 2, 3 or 4 days prior to MCAO (22.8, 25.9 and 20.5%, respectively). The beneficial effect of LPS pre-treatment was completely nullified by concurrent administration of TNFbp. On this basis, the tolerance to ischemia induced by LPS is likely to be mediated by TNF- α.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(96)01383-2