Comprehensive, human cellular protein databases and their implication for the study of genome organization and function

Comprehensive, computerized databases of cellular protein information derived from the analysis of two-dimensional gels, together with recently developed techniques to microsequence proteins offer a new dimension to the study of genome organization and function. In particular, human protein database...

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Bibliographic Details
Published in:FEBS letters 1989-02, Vol.244 (2), p.247-254
Main Authors: Celis, Julio E., Ratz, Gitte P., Madsen, Peder, Gesser, Borbala, Lauridsen, Jette B., Kwee, Sianette, Rasmussen, Hanne Holm, Nielsen, Henrik V., Crüger, Dorthe, Basse, Bodil, Leffers, Henrik, Honoré, Bent, Møller, Olaf, Celis, Ariana, Vandekerckhove, Joel, Bauw, Guy, van Damme, Jozef, Puype, Magda, Van den Bulcke, Marc
Format: Article
Language:English
Subjects:
2D, two-dimensional
Amino Acid Sequence
Cloning
data banks
Genes
Genome function
Genome organization
Genome sequencing
genomes
Humans
IEF, isoelectric focusing
Information Systems
man
Microsequencing
NEPHGE, non-equilibrium pH gradient electrophoresis
PCNA, proliferating cell nuclear antigen
Protein database
Proteins - genetics
Proteins - metabolism
PTH, phenylthiohydantoin
TFA, trifluoroacetic acid
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Summary:Comprehensive, computerized databases of cellular protein information derived from the analysis of two-dimensional gels, together with recently developed techniques to microsequence proteins offer a new dimension to the study of genome organization and function. In particular, human protein databases provide an ideal framework in which to focus the human genome sequencing effort.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(89)80538-1