Spindle Cell Carcinoma of the Breast

Spindle cell carcinoma is a rare breast tumor. We present herein three cases of spindle cell carcinoma of the breast and review its characteristics from the literature. Spindle cell carcinoma frequently forms a large and well-circumscribed tumor with gross cyst formation. Histologically, its dominan...

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Bibliographic Details
Published in:Japanese journal of clinical oncology 1997-02, Vol.27 (1), p.46-50
Main Authors: Maemura, Michio, Yuichilino, Oyama, Tetsunari, Hikino, Toshiaki, Yokoe, Takao, Takei, Hiroyuki, Horiguchi, Jun, Ohwada, Susumu, Nakajima, Takashi, Morishita, Yasuo
Format: Article
Language:English
Subjects:
Aged
breast cancer
Breast Neoplasms - chemistry
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - pathology
Carcinoma - chemistry
Carcinoma - diagnostic imaging
Carcinoma - pathology
carcinosarcoma
cystic formation
Female
Humans
Immunohistochemistry
Keratins - analysis
Middle Aged
Prognosis
spindle cell carcinoma
Ultrasonography, Mammary
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Summary:Spindle cell carcinoma is a rare breast tumor. We present herein three cases of spindle cell carcinoma of the breast and review its characteristics from the literature. Spindle cell carcinoma frequently forms a large and well-circumscribed tumor with gross cyst formation. Histologically, its dominant component is of sheets of spindle shaped cells, and it includes such contiguous carcinoma components as squamous differentiation or invasive ductal carcinoma. Estrogen receptor expression and lymph node metastasis tend to be low. Despite the sarcomatous features, spindle cells are likely to be derived from epithelial cells of mammary glands. Immunohistochemical and ultrastructural examination demonstrated the expression of keratin and the desmosome-like junctional structure in the spindle cell components. Relatively favorable prognosis is expected in spindle cell carcinoma of the breast compared to common breast carcinoma.
ISSN:0368-2811
1465-3621
1465-3621
DOI:10.1093/jjco/27.1.46