Biochemistry and physiology of gastrointestinal somatostatin

Somatostatin, a tetradecapeptide initially isolated from the ovine hypothalamus, is widely distributed throughout the gastrointestinal tract where it may act as a hormone, local chemical messenger, or neurotransmitter to elicit many physiological actions. Release of somatostatin from D cells in the...

Full description

Saved in:
Bibliographic Details
Published in:Digestive diseases and sciences 1989-03, Vol.34 (3 Suppl), p.5S-S13
Main Authors: Lucey, M R, Yamada, T
Format: Article
Language:English
Subjects:
Animals
Digestive System - metabolism
Digestive System Physiological Phenomena
Humans
Somatostatin - metabolism
Somatostatin - pharmacology
Somatostatin - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Somatostatin, a tetradecapeptide initially isolated from the ovine hypothalamus, is widely distributed throughout the gastrointestinal tract where it may act as a hormone, local chemical messenger, or neurotransmitter to elicit many physiological actions. Release of somatostatin from D cells in the gut is regulated by mechanisms that are both dependent on and independent of cAMP. In most cases somatostatin acts to inhibit the function of its target cells. It performs this action in part via pertussis-toxin-sensitive inhibitory guanine nucleotide-binding proteins that regulate adenylate cyclase activity. Other mechanisms may involve sites of action distal to intracellular second messenger systems.
ISSN:0163-2116
1573-2568
DOI:10.1007/bf01536041