Deficiency of total collagen content and of deoxypyridinoline in intracranial aneurysm walls

The tissue contents of total collagen and of 3-hydroxypyridinium cross-links, pyridinoline (PYD) and deoxypyridinoline (DPD), were measured in 15 samples of human aneurysms of Willis' Circle obtained at surgery and in 25 autopsy control samples of intracranial arteries of Willis' Circle ob...

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Bibliographic Details
Published in:FEBS letters 1997-03, Vol.404 (2), p.303-306
Main Authors: Gaetani, Paolo, Tartara, Fulvio, Tancioni, Flavio, Rodriguez y Baena, Riccardo, Casari, Erminia, Alfano, Massimo, Grazioli, Vittorio
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Amino Acids - analysis
Biomarkers
Chromatography, High Pressure Liquid
Circle of Willis - chemistry
Circle of Willis - pathology
Collagen
Collagen - analysis
Collagen - chemistry
Deoxypyridinoline
Humans
Intracranial aneurysm
Intracranial Aneurysm - pathology
Intracranial Aneurysm - surgery
Middle Aged
Pyridinoline
Reference Values
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Summary:The tissue contents of total collagen and of 3-hydroxypyridinium cross-links, pyridinoline (PYD) and deoxypyridinoline (DPD), were measured in 15 samples of human aneurysms of Willis' Circle obtained at surgery and in 25 autopsy control samples of intracranial arteries of Willis' Circle obtained from 6 subjects who died of other causes than cerebral hemorrhage. PYD and DPD were detected fluorimetrically after HPLC separation. Total collagen content was significantly lower ( P
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(97)00149-X