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In a vaccine model, selected substitution of a highly stimulatory T cell epitope of hen's egg lysozyme into a Salmonella flagellin does not result in a homologous, specific, cellular immune response and may alter the way in which the total antigen is processed
A 13 amino acid peptide corresponding to a potent BALB c mouse T cell epitope of hen's egg lysozyme (HEL) was substituted singly at five sites in the d flagellin of Salmonella muenchen. The resulting chimeric proteins were unable to expand T cells capable of being stimulated by the HEL epitope...
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Published in: | Vaccine 1997-02, Vol.15 (3), p.321-324 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | A 13 amino acid peptide corresponding to a potent
BALB
c
mouse T cell epitope of hen's egg lysozyme (HEL) was substituted singly at five sites in the
d flagellin of
Salmonella muenchen. The resulting chimeric proteins were unable to expand T cells capable of being stimulated by the HEL epitope and induced T cell populations which either failed to respond or responded at a low level to a normally highly stimulatory flagellin T cell epitope that was present in all chimeras. The results suggested that substitution of a T cell epitope in flagellin may alter the processing of the resulting immunogen. |
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ISSN: | 0264-410X 1873-2518 |
DOI: | 10.1016/S0264-410X(96)00167-3 |