Carbonic anhydrase localization to perivenous hepatocytes

It was shown by immunohistochemical methods, using antisera against highly purified carbonic anhydrases CA I, II and III, that CA II and CA III are specifically located in hepatocytes around central veins of adult rat livers. CA II was found in these perivenous hepatocytes of both male and female ra...

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Bibliographic Details
Published in:Acta physiologica Scandinavica 1989-02, Vol.135 (2), p.163-167
Main Authors: CARTER, N., WISTRAND, P. J., LÖNNERHOLM, G.
Format: Article
Language:English
Subjects:
Animals
bicarbonate secretion
Bicarbonates - secretion
bile
Biological and medical sciences
carbonic anhydrase
Carbonic Anhydrases - metabolism
Female
Fluorescent Antibody Technique
Fundamental and applied biological sciences. Psychology
isozymes
liver
Liver - cytology
Liver - enzymology
Liver. Bile. Biliary tracts
Male
Rats
Rats, Inbred Strains
Sex Factors
Vertebrates: digestive system
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Summary:It was shown by immunohistochemical methods, using antisera against highly purified carbonic anhydrases CA I, II and III, that CA II and CA III are specifically located in hepatocytes around central veins of adult rat livers. CA II was found in these perivenous hepatocytes of both male and female rats. Its physiological role is probably to facilitate the secretion of bicarbonate ions by these cells into canalicular bile. CA III and CA I were found in the same hepatocytes but only in the livers of male rats. The function of CA I and CA II exclusively in these cells of male rats cannot be simply explained.
ISSN:0001-6772
1365-201X
DOI:10.1111/j.1748-1716.1989.tb08563.x