BMY-28438(3, 7-DIHYDROXYTROPOLONE), A NEW ANTITUMOR ANTIBIOTIC ACTIVE AGAINST B16 MELANOMA: II. TAXONOMY OF PRODUCING ORGANISM

In the course of 2 screening program, a new antibiotic, BMY-28438, was found to show antitumor and weak antibacterial activities, and to be an analog of tropolone. This paper describes the taxonomic characterization of the producing organism. Strain K611-97 was isolated from a soil sample collected...

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Bibliographic Details
Published in:Journal of antibiotics 1989/02/25, Vol.42(2), pp.317-321
Main Authors: TOMITA, KOJI, HOSHINO, YUTAKA, NAKAKITA, YASUKAZU, UMEZAWA, SACHIKO, MIYAKI, TAKEO, OKI, TOSHIKAZU, KAWAGUCHI, HIROSHI
Format: Article
Language:English
Subjects:
3,7-dihydroxytropolone
Animals
antibiotic BMY-28438
Antibiotics, Antineoplastic - isolation & purification
Antibiotics, Antineoplastic - pharmacology
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
antitumor antibiotics
Applied microbiology
Biological and medical sciences
Cell Cycle - drug effects
Cell Line - drug effects
Chemotherapic agents
Fundamental and applied biological sciences. Psychology
Melanoma, Experimental - pathology
Microbiology
Soil Microbiology
Streptomyces - classification
Streptomyces - metabolism
Streptomyces - ultrastructure
tropolone
Tropolone - analogs & derivatives
Tropolone - isolation & purification
Tropolone - pharmacology
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Summary:In the course of 2 screening program, a new antibiotic, BMY-28438, was found to show antitumor and weak antibacterial activities, and to be an analog of tropolone. This paper describes the taxonomic characterization of the producing organism. Strain K611-97 was isolated from a soil sample collected in Uttar Pradesh State, India.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.42.317