Blunted serotonin response to fenfluramine challenge in premenstrual dysphoric disorder

OBJECTIVE: Indirect evidence suggests that abnormalities in serotonergic function may be involved in the pathogenesis of premenstrual dysphoric disorder. The goal of this study was to test the hypothesis of serotonergic deficiency in premenstrual dysphoric disorder by measuring the prolactin respons...

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Bibliographic Details
Published in:The American journal of psychiatry 1997-04, Vol.154 (4), p.556-558
Main Authors: FITZGERALD, M, MALONE, K. M, LI, S, HARRISON, W. M, MCBRIDE, P. A, ENDICOTT, J, COOPER, T, MANN, J. J
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Ambulatory Care
Biological and medical sciences
Endocrine system
Female
Fenfluramine - pharmacology
Humans
Luteal Phase - physiology
Medical sciences
Miscellaneous
Mood disorders
PMS
Premenstrual syndrome
Premenstrual Syndrome - blood
Premenstrual Syndrome - diagnosis
Premenstrual Syndrome - physiopathology
Prescription drugs
Prolactin - blood
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Serotonin - blood
Serotonin - physiology
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Summary:OBJECTIVE: Indirect evidence suggests that abnormalities in serotonergic function may be involved in the pathogenesis of premenstrual dysphoric disorder. The goal of this study was to test the hypothesis of serotonergic deficiency in premenstrual dysphoric disorder by measuring the prolactin response to fenfluramine. METHOD: The authors administered the serotonin-releasing drug dl-fenfluramine in a placebo-controlled protocol to nine women with premenstrual dysphoric disorder and 11 healthy female volunteers in the luteal phase of the menstrual cycle. RESULTS: Compared to the normal subjects, the women with premenstrual dysphoric disorder had a significantly blunted prolactin response to fenfluramine. CONCLUSIONS: Premenstrual dysphoric disorder appears to be associated with serotonergic deficiency.
ISSN:0002-953X
1535-7228
DOI:10.1176/ajp.154.4.556