Large-scale mammalian cell culture

Mammalian cell culture continues to draw major research efforts. A great deal of progress has recently been made in cellular physiology, especially in factors adversely affecting cell growth or viability. Through molecular genetic manipulation, cells are more readily cultivated in a medium free of a...

Full description

Saved in:
Bibliographic Details
Published in:Current opinion in biotechnology 1997-04, Vol.8 (2), p.148-153
Main Authors: Hu, Wei-Shou, Aunins, John G
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Bioreactors
Biotechnology - instrumentation
Biotechnology - methods
Cell Culture Techniques - instrumentation
Cell Culture Techniques - methods
Cell Death
Cell Line
Culture Media
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mammalian cell culture continues to draw major research efforts. A great deal of progress has recently been made in cellular physiology, especially in factors adversely affecting cell growth or viability. Through molecular genetic manipulation, cells are more readily cultivated in a medium free of animal proteins. Achieving a high cell concentration and high viability continue to be common themes in engineering research. The need to implement a control policy for fed-batch and perfusion cultures has prompted increased efforts in process monitoring and control. Integrating these advances will be beneficial for ensuring product quality and process consistency.
ISSN:0958-1669
1879-0429
DOI:10.1016/S0958-1669(97)80093-6