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Time profile of the haemodynamic effects of terlipressin in portal hypertension

Background/Aims: Terlipressin is a long-acting vasopressin analogue that has been proved useful in the treatment of varicel haemorrhage. This study investigates the time profile of the haemodynamic effects of terlipressin on portal hypertension as well as the efficacy in decreasing portal pressure a...

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Published in:Journal of hepatology 1997-03, Vol.26 (3), p.621-627
Main Authors: Escorsell, Àngels, Bandi, Juan Carlos, Moitinho, Eduardo, Feu, Faust, García-Pagán, Juan Carlos, Bosch, Jaume, Rodés, Joan
Format: Article
Language:English
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Summary:Background/Aims: Terlipressin is a long-acting vasopressin analogue that has been proved useful in the treatment of varicel haemorrhage. This study investigates the time profile of the haemodynamic effects of terlipressin on portal hypertension as well as the efficacy in decreasing portal pressure and collateral blood flow of reduced doses, suitable for longer therapy to prevent early rebleeding. Methods: Splanchnic and systemic haemodynamics were measured in 23 patients with cirrhosis and portal hypertension in baseline conditions and at 30 min, 1, 2, 3 and/or 4 h after the double-blind administration of a single intravenous injection of 1 mg ( n=8) or 2 mg ( n=8) of terlipressin, or placebo ( n=7). Results: Placebo caused no significant effects. At 30 min of terlipressin administration, the hepatic venous pressure gradient (1 mg: −16±9%, 2 mg: −21±11%; p
ISSN:0168-8278
1600-0641
DOI:10.1016/S0168-8278(97)80428-X