INHIBITION OF TYROSINE PROTEIN KINASE ACTIVITY BY SYNTHETIC ISOFLAVONES AND FLAVONES

Tyrosine protein kinase is known to be associated with oncogene products of the retroviral src gene family. This kinase activity is closely correlated with the ability of retroviruses to transform cells, since mutants of viruses which lack tyrosine kinase activity are defective in malignant transfor...

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Bibliographic Details
Published in:Journal of antibiotics 1989/02/25, Vol.42(2), pp.340-343
Main Authors: OGAWARA, HIROSHI, AKIYAMA, TETSU, WATANABE, SHUN-ICHI, ITO, NORIKI, KOBORI, MASATO, SEODA, YOSHIKO
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Avian Sarcoma Viruses - growth & development
Biological and medical sciences
Cell Line
ErbB Receptors - metabolism
Flavonoids - pharmacology
General aspects
genistein
Isoflavones - pharmacology
Medical sciences
Pharmacology. Drug treatments
protein-tyrosine kinase
Protein-Tyrosine Kinases - antagonists & inhibitors
Rous sarcoma virus
Structure-Activity Relationship
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Summary:Tyrosine protein kinase is known to be associated with oncogene products of the retroviral src gene family. This kinase activity is closely correlated with the ability of retroviruses to transform cells, since mutants of viruses which lack tyrosine kinase activity are defective in malignant transformation. A specific inhibitor for tyrosine protein kinase is expected to be a good tool for understanding the physiological role of tyrosine-phosphorylation of the various functional cellular proteins. In this line of screening, the authors isolated genistein, an isoflavone, from fermentation broth of a Pseudomonas species. The authors report here the inhibitory effect of isoflavones and flavones on tyrosine protein kinase activity and growth of Rous sarcoma virus (RSV)-transformed cells.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.42.340