Carcinoma of the Thyroid Manifested as Hyperthyroidism Caused by Functional Bone Metastasis

A rare case of hyperthyroidism in the presence of a functioning bone metastasis secondary to an occult thyroid cancer is reported. A 59-year-old woman's pelvic bone metastasis was much too extensive and hypervascular to permit resection. An I-131 scan showed striking activity in the pelvic meta...

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Bibliographic Details
Published in:Clinical nuclear medicine 1997-04, Vol.22 (4), p.227-230
Main Authors: IKEJIRI, KOJI, FURUYAMA, MASATO, MURANAKA, TORU, ANAI, HIDEAKI, TAKEO, SADANORI, SAKAI, KIKUO, SAKU, MOTONORI, YOSHIDA, KOJI
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bone Neoplasms - complications
Bone Neoplasms - diagnosis
Bone Neoplasms - secondary
Bone Neoplasms - therapy
Carcinoma, Papillary, Follicular - complications
Carcinoma, Papillary, Follicular - diagnosis
Carcinoma, Papillary, Follicular - secondary
Carcinoma, Papillary, Follicular - therapy
Combined Modality Therapy
Embolization, Therapeutic
Endocrine glands. Genital system. Mammary gland
Female
Hormones, Ectopic - biosynthesis
Humans
Hyperthyroidism - etiology
Investigative techniques, diagnostic techniques (general aspects)
Iodine Radioisotopes - therapeutic use
Medical sciences
Middle Aged
Radionuclide investigations
Thyroid Hormones - biosynthesis
Thyroid Neoplasms - pathology
Thyroid Neoplasms - therapy
Thyroidectomy
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Summary:A rare case of hyperthyroidism in the presence of a functioning bone metastasis secondary to an occult thyroid cancer is reported. A 59-year-old woman's pelvic bone metastasis was much too extensive and hypervascular to permit resection. An I-131 scan showed striking activity in the pelvic metastasis, which reflected ectopic excessive production of thyroid hormone by a functioning metastatic thryoid carcinoma. After total thyroidectomy, the patient received I-131 ablation and transcutaneous intra-arterial embolization therapy but her metastasis progressively enlarged. Microscopically, concomitant follicular and papillary cancer was found in close proximity to the thyroid. The patient now has vertebral metastases, and her hyperthyroid state still requires methymazole to prevent thyrotoxicosis.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-199704000-00003