Factor-derived subsyndromes of schizophrenia and familial morbid risks

Factor analysis was performed on OPCRIT checklist ratings from 66 patients with RDC schizophrenia. Eight substantive factors were found, characterised respectively by: positive formal thought disorder; first rank delusions; first rank hallucinations; inappropriate affect/bizarre behaviour; negative...

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Bibliographic Details
Published in:Schizophrenia research 1997-02, Vol.23 (3), p.231-238
Main Authors: Cardno, Alastair G., Holmans, Peter A., Harvey, Ian, Williams, Maureen B., Owen, Michael J., McGuffin, Peter
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Chi-Square Distribution
Classification
Cross-Sectional Studies
Factor analysis
Factor Analysis, Statistical
Family
Family Health
Female
Humans
Logistic Models
Male
Medical sciences
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - classification
Schizophrenia - genetics
Schizophrenia - physiopathology
United Kingdom
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Summary:Factor analysis was performed on OPCRIT checklist ratings from 66 patients with RDC schizophrenia. Eight substantive factors were found, characterised respectively by: positive formal thought disorder; first rank delusions; first rank hallucinations; inappropriate affect/bizarre behaviour; negative symptoms; grandiose/bizarre delusions; delusions of influence/persecution; and other hallucinations. A history of schizophrenia and other non-affective psychoses was ascertained in the probands' first-degree relatives using a family history approach. Illness in relatives was best predicted by probands' scores on subsyndromes derived from the inappropriate affect/bizarre behaviour and positive formal thought disorder factors.
ISSN:0920-9964
1573-2509
DOI:10.1016/S0920-9964(96)00093-X