Genetic Heterogeneity of Familial Atrial Myxoma Syndromes (Carney Complex)

Familial atrial myxomas may present as a component of the Carney complex, an autosomal dominant multiple neoplasia and lentiginosis syndrome. Although a gene defect for the Carney complex in some families maps to chromosome 2p, this syndrome is genetically heterogeneous, and other genetic loci also...

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Bibliographic Details
Published in:The American journal of cardiology 1997-04, Vol.79 (7), p.994-995
Main Authors: Basson, Craig T., MacRae, Calum A., Korf, Bruce, Merliss, Andrew
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cardiology. Vascular system
Cardiovascular disease
Child
Chromosomes, Human, Pair 2
Female
Genes
Genetic Heterogeneity
Genetics
Heart
Heart Atria
Heart Neoplasms - genetics
Humans
Lod Score
Male
Medical sciences
Middle Aged
Myxoma - genetics
Neoplastic Syndromes, Hereditary - genetics
Pedigree
Risk Factors
Tumors of the heart
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Description
Summary:Familial atrial myxomas may present as a component of the Carney complex, an autosomal dominant multiple neoplasia and lentiginosis syndrome. Although a gene defect for the Carney complex in some families maps to chromosome 2p, this syndrome is genetically heterogeneous, and other genetic loci also produce familial atrial myxomas.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(97)00033-7