Functional Properties of Neuronal Nicotinic Acetylcholine Receptor Channels Expressed in Transfected Human Cells

To study how subunit composition affects the functional properties of neuronal nicotinic acetylcholine receptors (nAChRs), we examined the behaviour of acetylcholine (ACh)‐induced single‐channel currents in human BOSC 23 cells transiently transfected with various subunit cDNA combinations. For all n...

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Bibliographic Details
Published in:The European journal of neuroscience 1997-03, Vol.9 (3), p.480-488
Main Authors: Ragozzino, D., Fucile, S., Giovannelli, A., Grassi, F., Mileo, A. M., Ballivet, M., Alemà, S., Eusebi, F.
Format: Article
Language:English
Subjects:
Acetylcholine - pharmacology
Animals
Ca2+ transients
Chickens
Humans
laser confocal microscopy
Neurons - drug effects
patch-clamp
Patch-Clamp Techniques
Rats
Receptors, Nicotinic - drug effects
Receptors, Nicotinic - physiology
single-channel conductance
Transfection
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Summary:To study how subunit composition affects the functional properties of neuronal nicotinic acetylcholine receptors (nAChRs), we examined the behaviour of acetylcholine (ACh)‐induced single‐channel currents in human BOSC 23 cells transiently transfected with various subunit cDNA combinations. For all nAChRs examined (chick and rat α3β4, chick α
ISSN:0953-816X
1460-9568
DOI:10.1111/j.1460-9568.1997.tb01625.x