Oryzanol decreases cholesterol absorption and aortic fatty streaks in hamsters

Oryzanol is a class of nonsaponifiable lipids of rice bran oil (RBO). More specifically, oryzanol is a group of ferulic acid esters of triterpene alcohol and plant sterols. In experiment 1, the mechanisms of the cholesterol‐lowering action of oryzanol were investigated in 32 hamsters made hyperchole...

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Bibliographic Details
Published in:Lipids 1997-03, Vol.32 (3), p.303-309
Main Authors: Rong, N. (Jean Mayer USDA Human Nutrition Research Center on Aging, Boston, MA.), Ausman, L.M, Nicolosi, R.J
Format: Article
Language:English
Subjects:
Absorption
ACEITES VEGETALES
Animals
Aorta - drug effects
Aorta - metabolism
Aorta - pathology
ARROZ
ARTERIOSCLEROSE
ARTERIOSCLEROSIS
Arteriosclerosis - drug therapy
Arteriosclerosis - etiology
Arteriosclerosis - metabolism
Body Weight - drug effects
BRAN
CHOLESTEROL
Cholesterol - metabolism
Cholesterol - pharmacokinetics
cholesterol lowering action
Cholesterol, LDL - blood
Cholesterol, VLDL - blood
Coconut oil
COLESTEROL
Cricetinae
Diet
Esters
HUILE VEGETALE
Hypolipidemic Agents - pharmacology
Intestinal Mucosa - metabolism
Intestines - drug effects
Lipids
Lipids - blood
Lipoproteins - blood
Lipoproteins - drug effects
Liver - drug effects
Liver - metabolism
Macrophages - drug effects
Macrophages - metabolism
Male
Phenylpropionates - pharmacology
PLANT OILS
Plant Oils - chemistry
RICE
Rice Bran Oil
RIZ
Rodents
SALVADO
SON
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Summary:Oryzanol is a class of nonsaponifiable lipids of rice bran oil (RBO). More specifically, oryzanol is a group of ferulic acid esters of triterpene alcohol and plant sterols. In experiment 1, the mechanisms of the cholesterol‐lowering action of oryzanol were investigated in 32 hamsters made hypercholesterolemic by feeding chow‐based diets containing 5% coconut oil and 0.1% cholesterol with or without 1% oryzanol for 7 wk. Relative to the control animals, oryzanol treatment resulted in a significant reduction in plasma total cholesterol (TC) (28%, P
ISSN:0024-4201
1558-9307
DOI:10.1007/s11745-997-0037-9