Low-voltage-activated T-type Ca2+ channels

Although progress in our understanding of T channels and their physiological role has been slower than with other Ca2+ channels, it was clear during this two-day workshop that interest and research in the field remain very intense. Advances have been hampered by many factors: small current amplitude...

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Bibliographic Details
Published in:Trends in pharmacological sciences (Regular ed.) 1997-02, Vol.18 (2), p.37-42
Main Authors: Ertel, S I, Ertel, E A
Format: Article
Language:English
Subjects:
Animals
Calcium Channel Blockers - administration & dosage
Calcium Channel Blockers - pharmacology
Calcium Channel Blockers - therapeutic use
Calcium Channels - classification
Calcium Channels - drug effects
Calcium Channels - physiology
Cell Communication - physiology
Cell Division - physiology
Cloning, Molecular
Electrophysiology
Exons
Humans
Rats
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Summary:Although progress in our understanding of T channels and their physiological role has been slower than with other Ca2+ channels, it was clear during this two-day workshop that interest and research in the field remain very intense. Advances have been hampered by many factors: small current amplitude, lack of pharmacological tools, apparent heterogeneity, and lack of a cloned channel. Nevertheless, many interesting roles for T channels have been described, which point to a generally subtle modulatory action. Furthermore, recent results suggest that the above barriers might soon be abolished: new pharmacological tools (mibefradil and newer generation compounds) with T-channel selectivity are being developed and many groups claim to be close to cloning a T channel.
ISSN:0165-6147
DOI:10.1016/S0165-6147(96)01021-8