The development of long-term potentiation in hippocampus and neocortex

The development of long-term potentiation (LTP), an enduring alteration in synaptic efficacy following afferent activation, was examined in CA1 hippocampus and primary visual cortex of rat. Both regions show little LTP prior to postnatal day 5, demonstrate a maximal potentiated response around postn...

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Bibliographic Details
Published in:Neuropsychologia 1989, Vol.27 (1), p.31-39
Main Authors: Teyler, T.J., Perkins, A.T., Harris, Kristen M.
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Behavioral psychophysiology
Biological and medical sciences
Cerebral Cortex - physiology
Electric Stimulation
Evoked Potentials
Female
Fundamental and applied biological sciences. Psychology
Hippocampus - physiology
Memory - physiology
Mental Recall - physiology
Neurons - physiology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Inbred Strains
Synapses - physiology
Synaptic Transmission
Visual Cortex - physiology
Visual Pathways - physiology
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Summary:The development of long-term potentiation (LTP), an enduring alteration in synaptic efficacy following afferent activation, was examined in CA1 hippocampus and primary visual cortex of rat. Both regions show little LTP prior to postnatal day 5, demonstrate a maximal potentiated response around postnatal day 15, and a subsequent decline to adult levels. These results are discussed with respect to the underlying mechanism of action and behavioral significance of these critical-periond phenomena.
ISSN:0028-3932
1873-3514
DOI:10.1016/0028-3932(89)90088-2