l-tyrosine and nicotine induce synthesis of l-Dopa and norepinephrine in human lymphocytes

Catecholamines (CA) were studied in peripheral human lymphocytes in basal conditions as well as after l-tyrosine and/or acetylcholine (ACh) stimulation. Nicotinic and muscarinic receptor activation and blockade were assessed. CA were determined after ultrasonic cell disruption in peripheral lymphocy...

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Bibliographic Details
Published in:Journal of neuroimmunology 1997-04, Vol.74 (1), p.117-120
Main Authors: Musso, Natale R, Brenci, Sabrina, Indiveri, Francesco, Lotti, Gaetano
Format: Article
Language:English
Subjects:
Acetylcholine
Acetylcholine - pharmacology
Adult
Blood Cells - metabolism
Female
Humans
l-Dopa
l-tyrosine
Levodopa - biosynthesis
Lymphocytes
Lymphocytes - metabolism
Male
Muscarine
Muscarine - pharmacology
Nicotine
Nicotine - pharmacology
Norepinephrine
Norepinephrine - biosynthesis
Tyrosine - pharmacology
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Summary:Catecholamines (CA) were studied in peripheral human lymphocytes in basal conditions as well as after l-tyrosine and/or acetylcholine (ACh) stimulation. Nicotinic and muscarinic receptor activation and blockade were assessed. CA were determined after ultrasonic cell disruption in peripheral lymphocytes after incubation (1 h at 37°C) with the chemicals employed. l-tyrosine significantly increased ( P
ISSN:0165-5728
1872-8421
DOI:10.1016/S0165-5728(96)00212-3