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Hepatitis B and C virus and hepatocellular carcinoma
Antibody to hepatitis C virus (anti-HCV) was detected in 18·7% of patients with hepatocellular carcinoma (HCC) and in 10·9% of controls ( P < 0·001). The corresponding prevalences of hepatitis B surface antigen (HBsAg) were 59·3% and 50·0% ( P < 0·001). Using patients with non-hepatic disease...
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| Published in: | Transactions of the Royal Society of Tropical Medicine and Hygiene 1997, Vol.91 (1), p.38-41 |
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| container_end_page | 41 |
| container_issue | 1 |
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| container_title | Transactions of the Royal Society of Tropical Medicine and Hygiene |
| container_volume | 91 |
| creator | Olubuyide, I.O. Aliyu, B. Olalelye, O.A. Ola, S.O. Olawuyi, F. Malabu, U.H. Odemuyiwa, S.O. Odaibo, G.N. Cook, G.C. |
| description | Antibody to hepatitis C virus (anti-HCV) was detected in 18·7% of patients with hepatocellular carcinoma (HCC) and in 10·9% of controls (
P < 0·001). The corresponding prevalences of hepatitis B surface antigen (HBsAg) were 59·3% and 50·0% (
P < 0·001). Using patients with non-hepatic disease as controls, stepwise logistic regression analysis indicated that both anti-HCV (odds ratio 6·88%; 95% confidence interval [CI] 1·63–9·77) and HBsAg (odds ratio 6·46; 95% CI 1·68–18·13) were independent risk factors for HCC. Calculation of the incremental odds ratio indicated no interaction between hepatitis B virus (HBV) and HCV. Blood transfusion was a significant risk factor for acquiring HCV infection with odds ratios of 5·48 (95% CI 1·07–29·0) and 2·86 (95% CI 1·31–22·72) for HCC cases and controls, respectively. The mean age of HCC cases with HBsAg and anti-HCV was lower than that of HCC patients with anti-HCV alone (
P < 0·01). It is concluded that there is a high rate of HBV infection, and a low rate of HCV infection, among Nigerian patients with HCC. However, HBV and HCV are independent risk factors for the development of HCC, with HBV having an effect more rapidly. Screening of blood products for transfusion might minimize the risk of HCV transmission. |
| doi_str_mv | 10.1016/S0035-9203(97)90387-4 |
| format | article |
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P < 0·001). The corresponding prevalences of hepatitis B surface antigen (HBsAg) were 59·3% and 50·0% (
P < 0·001). Using patients with non-hepatic disease as controls, stepwise logistic regression analysis indicated that both anti-HCV (odds ratio 6·88%; 95% confidence interval [CI] 1·63–9·77) and HBsAg (odds ratio 6·46; 95% CI 1·68–18·13) were independent risk factors for HCC. Calculation of the incremental odds ratio indicated no interaction between hepatitis B virus (HBV) and HCV. Blood transfusion was a significant risk factor for acquiring HCV infection with odds ratios of 5·48 (95% CI 1·07–29·0) and 2·86 (95% CI 1·31–22·72) for HCC cases and controls, respectively. The mean age of HCC cases with HBsAg and anti-HCV was lower than that of HCC patients with anti-HCV alone (
P < 0·01). It is concluded that there is a high rate of HBV infection, and a low rate of HCV infection, among Nigerian patients with HCC. However, HBV and HCV are independent risk factors for the development of HCC, with HBV having an effect more rapidly. Screening of blood products for transfusion might minimize the risk of HCV transmission.</description><identifier>ISSN: 0035-9203</identifier><identifier>EISSN: 1878-3503</identifier><identifier>DOI: 10.1016/S0035-9203(97)90387-4</identifier><identifier>PMID: 9093625</identifier><identifier>CODEN: TRSTAZ</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adult ; Age Factors ; Antibodies, Viral - blood ; Biological and medical sciences ; Carcinoma, Hepatocellular - physiopathology ; Carcinoma, Hepatocellular - virology ; Case-Control Studies ; Female ; Hepacivirus - immunology ; Hepatitis B Surface Antigens - blood ; hepatitis B virus ; Hepatitis B virus - isolation & purification ; Hepatitis C - virology ; hepatitis C virus ; hepatocellular carcinoma ; Human viral diseases ; Humans ; Infectious diseases ; Liver Neoplasms - physiopathology ; Liver Neoplasms - virology ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Nigeria ; Risk Factors ; Transfusion Reaction ; Tropical medicine ; Viral diseases ; Viral hepatitis</subject><ispartof>Transactions of the Royal Society of Tropical Medicine and Hygiene, 1997, Vol.91 (1), p.38-41</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-37a898ff965ea22c2083f1c886b1cd5071b567db8a387242d513b00591cb3eab3</citedby><cites>FETCH-LOGICAL-c427t-37a898ff965ea22c2083f1c886b1cd5071b567db8a387242d513b00591cb3eab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2601085$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9093625$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Olubuyide, I.O.</creatorcontrib><creatorcontrib>Aliyu, B.</creatorcontrib><creatorcontrib>Olalelye, O.A.</creatorcontrib><creatorcontrib>Ola, S.O.</creatorcontrib><creatorcontrib>Olawuyi, F.</creatorcontrib><creatorcontrib>Malabu, U.H.</creatorcontrib><creatorcontrib>Odemuyiwa, S.O.</creatorcontrib><creatorcontrib>Odaibo, G.N.</creatorcontrib><creatorcontrib>Cook, G.C.</creatorcontrib><title>Hepatitis B and C virus and hepatocellular carcinoma</title><title>Transactions of the Royal Society of Tropical Medicine and Hygiene</title><addtitle>Trans R Soc Trop Med Hyg</addtitle><description>Antibody to hepatitis C virus (anti-HCV) was detected in 18·7% of patients with hepatocellular carcinoma (HCC) and in 10·9% of controls (
P < 0·001). The corresponding prevalences of hepatitis B surface antigen (HBsAg) were 59·3% and 50·0% (
P < 0·001). Using patients with non-hepatic disease as controls, stepwise logistic regression analysis indicated that both anti-HCV (odds ratio 6·88%; 95% confidence interval [CI] 1·63–9·77) and HBsAg (odds ratio 6·46; 95% CI 1·68–18·13) were independent risk factors for HCC. Calculation of the incremental odds ratio indicated no interaction between hepatitis B virus (HBV) and HCV. Blood transfusion was a significant risk factor for acquiring HCV infection with odds ratios of 5·48 (95% CI 1·07–29·0) and 2·86 (95% CI 1·31–22·72) for HCC cases and controls, respectively. The mean age of HCC cases with HBsAg and anti-HCV was lower than that of HCC patients with anti-HCV alone (
P < 0·01). It is concluded that there is a high rate of HBV infection, and a low rate of HCV infection, among Nigerian patients with HCC. However, HBV and HCV are independent risk factors for the development of HCC, with HBV having an effect more rapidly. Screening of blood products for transfusion might minimize the risk of HCV transmission.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Antibodies, Viral - blood</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Hepatocellular - physiopathology</subject><subject>Carcinoma, Hepatocellular - virology</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Hepacivirus - immunology</subject><subject>Hepatitis B Surface Antigens - blood</subject><subject>hepatitis B virus</subject><subject>Hepatitis B virus - isolation & purification</subject><subject>Hepatitis C - virology</subject><subject>hepatitis C virus</subject><subject>hepatocellular carcinoma</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Liver Neoplasms - physiopathology</subject><subject>Liver Neoplasms - virology</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Nigeria</subject><subject>Risk Factors</subject><subject>Transfusion Reaction</subject><subject>Tropical medicine</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><issn>0035-9203</issn><issn>1878-3503</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFkF1LwzAUhoMoc05_gtALEb2oniRNk1yJDnXiRPADxJuQpilGu3Ym7dB_b7uN3XqVA-9zTl4ehA4xnGHA6fkzAGWxJEBPJD-VQAWPky00xIKLmDKg22i4QXbRXgifAIRhJgdoIEHSlLAhSiZ2rhvXuBBdRbrKo3G0cL4Ny_mjz2pjy7IttY-M9sZV9Uzvo51Cl8EerN8Rer25fhlP4unj7d34chqbhPAmplwLKYpCpsxqQgwBQQtshEgzbHIGHGcs5XkmdNedJCRnmGYATGKTUaszOkLHq7tzX3-3NjRq5kJfR1e2boPiQtKEQNKBbAUaX4fgbaHm3s20_1UYVG9LLW2pXoWSXC1tqX7vcP1Bm81svtla6-nyo3Wug9Fl4XVlXNhgJAUMosfiFeZCY382sfZfKuWUMzV5e1cP8ETZ9D5V046_WPG2k7dw1qtgnK2MzZ23plF57f4p_gcTOJNS</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>Olubuyide, I.O.</creator><creator>Aliyu, B.</creator><creator>Olalelye, O.A.</creator><creator>Ola, S.O.</creator><creator>Olawuyi, F.</creator><creator>Malabu, U.H.</creator><creator>Odemuyiwa, S.O.</creator><creator>Odaibo, G.N.</creator><creator>Cook, G.C.</creator><general>Elsevier Ltd</general><general>Royal Society of Tropical Medicine and Hygiene</general><general>Elsevier</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1997</creationdate><title>Hepatitis B and C virus and hepatocellular carcinoma</title><author>Olubuyide, I.O. ; Aliyu, B. ; Olalelye, O.A. ; Ola, S.O. ; Olawuyi, F. ; Malabu, U.H. ; Odemuyiwa, S.O. ; Odaibo, G.N. ; Cook, G.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-37a898ff965ea22c2083f1c886b1cd5071b567db8a387242d513b00591cb3eab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Antibodies, Viral - blood</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Hepatocellular - physiopathology</topic><topic>Carcinoma, Hepatocellular - virology</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Hepacivirus - immunology</topic><topic>Hepatitis B Surface Antigens - blood</topic><topic>hepatitis B virus</topic><topic>Hepatitis B virus - isolation & purification</topic><topic>Hepatitis C - virology</topic><topic>hepatitis C virus</topic><topic>hepatocellular carcinoma</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Liver Neoplasms - physiopathology</topic><topic>Liver Neoplasms - virology</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Nigeria</topic><topic>Risk Factors</topic><topic>Transfusion Reaction</topic><topic>Tropical medicine</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olubuyide, I.O.</creatorcontrib><creatorcontrib>Aliyu, B.</creatorcontrib><creatorcontrib>Olalelye, O.A.</creatorcontrib><creatorcontrib>Ola, S.O.</creatorcontrib><creatorcontrib>Olawuyi, F.</creatorcontrib><creatorcontrib>Malabu, U.H.</creatorcontrib><creatorcontrib>Odemuyiwa, S.O.</creatorcontrib><creatorcontrib>Odaibo, G.N.</creatorcontrib><creatorcontrib>Cook, G.C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olubuyide, I.O.</au><au>Aliyu, B.</au><au>Olalelye, O.A.</au><au>Ola, S.O.</au><au>Olawuyi, F.</au><au>Malabu, U.H.</au><au>Odemuyiwa, S.O.</au><au>Odaibo, G.N.</au><au>Cook, G.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatitis B and C virus and hepatocellular carcinoma</atitle><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle><addtitle>Trans R Soc Trop Med Hyg</addtitle><date>1997</date><risdate>1997</risdate><volume>91</volume><issue>1</issue><spage>38</spage><epage>41</epage><pages>38-41</pages><issn>0035-9203</issn><eissn>1878-3503</eissn><coden>TRSTAZ</coden><abstract>Antibody to hepatitis C virus (anti-HCV) was detected in 18·7% of patients with hepatocellular carcinoma (HCC) and in 10·9% of controls (
P < 0·001). The corresponding prevalences of hepatitis B surface antigen (HBsAg) were 59·3% and 50·0% (
P < 0·001). Using patients with non-hepatic disease as controls, stepwise logistic regression analysis indicated that both anti-HCV (odds ratio 6·88%; 95% confidence interval [CI] 1·63–9·77) and HBsAg (odds ratio 6·46; 95% CI 1·68–18·13) were independent risk factors for HCC. Calculation of the incremental odds ratio indicated no interaction between hepatitis B virus (HBV) and HCV. Blood transfusion was a significant risk factor for acquiring HCV infection with odds ratios of 5·48 (95% CI 1·07–29·0) and 2·86 (95% CI 1·31–22·72) for HCC cases and controls, respectively. The mean age of HCC cases with HBsAg and anti-HCV was lower than that of HCC patients with anti-HCV alone (
P < 0·01). It is concluded that there is a high rate of HBV infection, and a low rate of HCV infection, among Nigerian patients with HCC. However, HBV and HCV are independent risk factors for the development of HCC, with HBV having an effect more rapidly. Screening of blood products for transfusion might minimize the risk of HCV transmission.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>9093625</pmid><doi>10.1016/S0035-9203(97)90387-4</doi><tpages>4</tpages></addata></record> |
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| ispartof | Transactions of the Royal Society of Tropical Medicine and Hygiene, 1997, Vol.91 (1), p.38-41 |
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| source | Oxford Journals Online |
| subjects | Adult Age Factors Antibodies, Viral - blood Biological and medical sciences Carcinoma, Hepatocellular - physiopathology Carcinoma, Hepatocellular - virology Case-Control Studies Female Hepacivirus - immunology Hepatitis B Surface Antigens - blood hepatitis B virus Hepatitis B virus - isolation & purification Hepatitis C - virology hepatitis C virus hepatocellular carcinoma Human viral diseases Humans Infectious diseases Liver Neoplasms - physiopathology Liver Neoplasms - virology Logistic Models Male Medical sciences Middle Aged Multivariate Analysis Nigeria Risk Factors Transfusion Reaction Tropical medicine Viral diseases Viral hepatitis |
| title | Hepatitis B and C virus and hepatocellular carcinoma |
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