Both the cholinergic and non-cholinergic components of airway excitation are inhibited by morphine in the guinea-pig

In order to investigate the effect of morphine on the excitatory and inhibitory non‐adrenergic, non‐cholinergic (NANC) neurotransmission and cholinergic neurotransmission in airways, ring preparations from guinea‐pig trachea and bronchi were studied. The preparations were stimulated by electrical fi...

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Bibliographic Details
Published in:Acta physiologica Scandinavica 1989-03, Vol.135 (3), p.411-415
Main Authors: JOHANSSON, I.G.M., GRUNDSTRÖM, N., ANDERSSON, R.G.G.
Format: Article
Language:English
Subjects:
Air breathing
Animals
Biological and medical sciences
Bronchi - drug effects
Bronchi - innervation
Electric Stimulation
Fundamental and applied biological sciences. Psychology
Guinea Pigs
guinea-pig
irway
Male
morphine
Morphine - pharmacology
Muscle Contraction - drug effects
Muscle, Smooth - drug effects
Neuromuscular Junction - drug effects
neuronal inhibition
Receptors, Cholinergic - drug effects
Respiratory Muscles - drug effects
Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics
Synaptic Transmission - drug effects
Trachea - drug effects
Trachea - innervation
Vertebrates: respiratory system
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Summary:In order to investigate the effect of morphine on the excitatory and inhibitory non‐adrenergic, non‐cholinergic (NANC) neurotransmission and cholinergic neurotransmission in airways, ring preparations from guinea‐pig trachea and bronchi were studied. The preparations were stimulated by electrical field stimulation to elicit contractions and relaxations. Both cholinergic and NANC contractions were reduced by morphine in a dose‐dependent way, while the inhibitory NANC neurotransmission was unaffected. A morphine concentration of 10‐4m reduced the NANC contractions to 20.8± 1.5% of the control contractions and the cholinergic contractions to 49.7±4.2%. The effect of morphine on cholinergic neurotransmission was completely inhibited by naloxone (10‐5m) while the effect of morphine on NANC contractions only was reduced to 67.6± 5.6% of the control contractions. It is suggested that morphine influences the excitatory neurotransmission via pre‐junctional sites, since morphine had no effect on the acetylcholine‐induced contractions.
ISSN:0001-6772
1365-201X
DOI:10.1111/j.1748-1716.1989.tb08595.x