A simple and reliable method for delivering small fluid volumes to the brain of a freely moving rat

A stepper motor-powered micropump for making intracerebral microinjections in freely moving animals is described. The micropump is capable of delivering fluid volumes of up to 20 μl in steps of 17 nl The system does not require a fluid swivel, delivers injections rapidly, maintains long-term calibra...

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Bibliographic Details
Published in:Journal of neuroscience methods 1997-03, Vol.72 (1), p.35-38
Main Authors: Hesse, Gary W, Stellar, James R, Chevrette, Jessica
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain - physiology
Fundamental and applied biological sciences. Psychology
General aspects. Models. Methods
Infusion Pumps
Intracranial Injection
Locomotion - physiology
Microinjection
Microinjections - instrumentation
Microinjections - methods
Micropump
Rats
Vertebrates: nervous system and sense organs
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Description
Summary:A stepper motor-powered micropump for making intracerebral microinjections in freely moving animals is described. The micropump is capable of delivering fluid volumes of up to 20 μl in steps of 17 nl The system does not require a fluid swivel, delivers injections rapidly, maintains long-term calibration accuracy and is not susceptible to blockage of the cannula.
ISSN:0165-0270
1872-678X
DOI:10.1016/S0165-0270(96)00152-5