Phaeochromocytoma: a ten-year survey

• Published in: QJM : An International Journal of Medicine 1997-01, Vol.90 (1), p.51-60
• Main Authors: Loh, K.-C., Shlossberg, A.H., Abbott, E.C., Salisbury, S.R., Tan, M.-H.
• Format: Article
• Language: English
• Subjects: Adrenal Gland Neoplasms - complications; Adrenal Gland Neoplasms - diagnosis; Adrenal Gland Neoplasms - metabolism; Adrenal Gland Neoplasms - therapy; Adrenals. Adrenal axis. Renin-angiotensin system (diseases); Adult; Age of Onset; Aged; Aged, 80 and over; Arrhythmias, Cardiac - complications; Biological and medical sciences; Child; Combined Modality Therapy; Endocrinopathies; Female; Headache - complications; Humans; Hypertension - complications; Male; Medical sciences; Middle Aged; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Pheochromocytoma - complications; Pheochromocytoma - diagnosis; Pheochromocytoma - metabolism; Pheochromocytoma - therapy; Recurrence; Retrospective Studies; Treatment Outcome; Urinalysis
• ISSN: 1460-2725; 1460-2393
• DOI: 10.1093/qjmed/90.1.51

We retrospectively evaluated our experience with phaeochromocytoma from January 1986 to December 1995. There were 18 patients with surgically-proven phaeochromocytoma: three males, 15 females, aged 12–81 years (mean 42 years) at diagnosis. Sixteen were hypertensive; only 6/18 presented with two or more of the classical triad of headaches, palpitations and diaphoresis. One patient presented with hypertensive crisis. Duration of symptoms prior to diagnosis was 2 weeks to 6 years, mean 16.4 months. Sixteen patients had adrenal tumours and two had extra-adrenal tumours or para-gangliomas. One had bilateral adrenal tumours and two had a combination of both adrenal and extra-adrenal tumours. There were four familial cases: two had multiple endocrine neoplasia type IIA (MEN-IIA), one had neurofibromatosis type I (NF-I) and one von Hippel-Lindau (VHL) disease. One patient had Cushing's syndrome arising from ectopic production of adrenocorticotropic hormone (ACTH) by the phaeochromocytoma. Disease was recurrent in three patients. Pre-operative diagnosis was confirmed mainly by elevated urine vanillylmandelic acid (VMA) and/or catecholamine levels. Twelve patients had plasma catecholamine determinations: noradrenaline was elevated in all, adrenaline in six and dopamine in two. Pre-operative localization was by CT scan or MR imaging in all patients. At follow-up of 1–10 years (median 4.8 years), 15 patients were cured surgically while two were asymptomatic despite recurrence of disease. One patient with recurrent paragangliomas died post-operatively.