Antibody responses to HPV16 virus-like particles in women with cervical intraepithelial neoplasia infected with a variant HPV16

Ellis et al identified a naturally occurring mutation in the human papillomavirus type 16 E6 protein that results in an amino acid substitution within a putative HLA-B7 restricted cytotoxic T lymphocyte epitope.

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Bibliographic Details
Published in:The Lancet (British edition) 1997-04, Vol.349 (9058), p.1069-1070
Main Authors: Ellis, JRM, Etherington, I, Galloway, D, Luesley, D, Young, LS
Format: Article
Language:English
Subjects:
Amino acids
Antibodies, Viral - blood
Biological and medical sciences
Cervical cancer
Cervical Intraepithelial Neoplasia - immunology
Cervical Intraepithelial Neoplasia - virology
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Immunoglobulin G
Lymphocytes
Medical sciences
Mutation
Papillomaviridae - immunology
Papillomavirus Infections - immunology
Papillomavirus Infections - virology
Proteins
Tumor Virus Infections - immunology
Tumor Virus Infections - virology
Tumors
Uterine Cervical Neoplasms - immunology
Uterine Cervical Neoplasms - virology
Viruses
Women
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Description
Summary:Ellis et al identified a naturally occurring mutation in the human papillomavirus type 16 E6 protein that results in an amino acid substitution within a putative HLA-B7 restricted cytotoxic T lymphocyte epitope.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(05)62292-1