N-acetylation and hydroxylation polymorphisms in type II diabetics with microvascular disturbances

The N-acetylation and hydroxylation (CYP2D6) genetic polymorphisms were assessed in 43 healthy subjects and in 84 type II (non-insulin-dependent) diabetics. The proportions of slow and fast acetylators as well as poor and extensive metabolisers in a group of diabetics suffering from microvascular di...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1997, Vol.51 (6), p.431-435
Main Authors: GAWRONSKA-SZKLARZ, B, GORNIK, W, PAWLIK, A, KUNICKI, P, WOJCICKI, J, SITKIEWICZ, D, SYCH, Z
Format: Article
Language:English
Subjects:
Acetylation
Adult
Aged
Associated diseases and complications
Biological and medical sciences
Debrisoquin
Diabetes Mellitus, Type 2 - genetics
Diabetes Mellitus, Type 2 - metabolism
Diabetes. Impaired glucose tolerance
Diabetic Angiopathies - genetics
Diabetic Angiopathies - metabolism
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Female
Gene Frequency
Humans
Hydroxylation
Male
Medical sciences
Middle Aged
Phenotype
Polymorphism, Genetic - genetics
Sulfamethazine
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Summary:The N-acetylation and hydroxylation (CYP2D6) genetic polymorphisms were assessed in 43 healthy subjects and in 84 type II (non-insulin-dependent) diabetics. The proportions of slow and fast acetylators as well as poor and extensive metabolisers in a group of diabetics suffering from microvascular disturbances (nephropathy, retinopathy and neuropathy) were compared with the control group and with diabetics without such complications. Sulphadimidine was used as a probe for polymorphic acetylation and debrisoquine for CYP2D6. Debrisoquine and its 4-OH metabolite were assayed by means of HPLC, and sulphadimidine using a modified Bratton-Marshall procedure. The frequency of the slow phenotype (63%) was significantly higher in diabetics with microvascular disturbances than in patients without diabetic complications (P < 0.005). In patients with type II diabetes (84), only the extensive phenotype of hydroxylation was observed.
ISSN:0031-6970
1432-1041
DOI:10.1007/s002280050226