Physical Characterization of the Methanol Solvate of Urapidil

The methanol solvate of urapidil was prepared and characterized by means of differential scanning calorimetry, thermogravimetric analysis, infrared spectroscopy, X‐ray powder diffraction, intrinsic dissolution rate, and solution calorimetry. The stoichiometry of the urapidil: methanol solvate was fo...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1989-01, Vol.78 (1), p.28-34
Main Authors: Botha, S.A., Caira, M.R., Guillory, J.K., Lötter, A.P.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Calorimetry, Differential Scanning
Chemical Phenomena
Chemistry, Physical
General pharmacology
Hydrogen Bonding
Medical sciences
Methanol
Microscopy, Electron, Scanning
Models, Chemical
Molecular Conformation
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
Piperazines - analysis
Solubility
Spectrophotometry, Infrared
Temperature
Thermogravimetry
X-Ray Diffraction
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Summary:The methanol solvate of urapidil was prepared and characterized by means of differential scanning calorimetry, thermogravimetric analysis, infrared spectroscopy, X‐ray powder diffraction, intrinsic dissolution rate, and solution calorimetry. The stoichiometry of the urapidil: methanol solvate was found to be 1:1.The crystal and molecular structures were determined from three‐dimensional X‐ray data.The stability of the solvate under different storage conditions was also determined.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600780109