Brain SPECT Evaluation of Cerebral Perfusion in Hemimegalencephaly

Hemimegalencephaly is a rare congenital neuronal migration disorder characterized by unilateral hypertrophy of a cerebral hemisphere. It can be an isolated abnormality, or it can be associated with neurocutaneous syndromes. Clinical manifestations include intractable motor seizures, impaired psychom...

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Published in:Clinical nuclear medicine 1997-04, Vol.22 (4), p.250-252
Main Authors: BAR-SEVER, ZVI, CONNOLLY, LEONARD P, BARNES, PATRICK D, TREVES, S TED
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain - abnormalities
Brain - diagnostic imaging
Cerebrovascular Circulation - physiology
Humans
Infant
Infant, Newborn
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging
Male
Medical sciences
Nervous system
Radionuclide investigations
Seizures - etiology
Tomography, Emission-Computed
Tomography, Emission-Computed, Single-Photon
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cited_by cdi_FETCH-LOGICAL-c4799-f7e3142e9798abf898c04a216e3a43b1c37ed4e08a4fcf9b6b397df67347439e3
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container_end_page 252
container_issue 4
container_start_page 250
container_title Clinical nuclear medicine
container_volume 22
creator BAR-SEVER, ZVI
CONNOLLY, LEONARD P
BARNES, PATRICK D
TREVES, S TED
description Hemimegalencephaly is a rare congenital neuronal migration disorder characterized by unilateral hypertrophy of a cerebral hemisphere. It can be an isolated abnormality, or it can be associated with neurocutaneous syndromes. Clinical manifestations include intractable motor seizures, impaired psychomotor development, hemiparesis, and hemianopsia. Prognosis is poor. Hemispherectomy is the treatment of choice. Brain SPECT is useful in excluding seizure foci or other perfusion abnormalities in the contralateral side before surgery. The authors report two cases of increased perfusion in the affected hemisphere relative to the contralateral hemisphere that contrast with previous reports of decreased perfusion in the abnormal side as determined scintigraphically.
doi_str_mv 10.1097/00003072-199704000-00009
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source LWW_医学期刊
subjects Biological and medical sciences
Brain - abnormalities
Brain - diagnostic imaging
Cerebrovascular Circulation - physiology
Humans
Infant
Infant, Newborn
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging
Male
Medical sciences
Nervous system
Radionuclide investigations
Seizures - etiology
Tomography, Emission-Computed
Tomography, Emission-Computed, Single-Photon
title Brain SPECT Evaluation of Cerebral Perfusion in Hemimegalencephaly
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