Immunosuppression in Paracoccidioidomycosis: T Cell Hyporesponsiveness to Two Paracoccidioides brasiliensis Glycoproteins that Elicit Strong Humoral Immune Response

To assess human cellular immune response to paracoccidioidomycosis (PCM), lymphocyte proliferative responses to purified antigens from Paracoccidioides brasiliensis were determined in healthy persons previously infected by the fungus (positive donors), in healthy noninfected persons (controls), and...

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Bibliographic Details
Published in:The Journal of infectious diseases 1997-05, Vol.175 (5), p.1263-1267
Main Authors: Benard, Gil, Mendes-Giannini, Maria José S., Juvenale, Michelangelo, Miranda, Elaine T., Duarte, Alberto J. S.
Format: Article
Language:English
Subjects:
Antibody Formation
Antigens
Antigens, Fungal - immunology
Biological and medical sciences
Blastomycoses and paracoccidioidomycosis
Cell walls
Cells, Cultured
Concise Communications
Cross reaction
Fungal infections
Fungal Proteins - immunology
Glycoproteins
Human mycoses
Humans
Immune Tolerance
Immunity, Cellular
Infectious diseases
Lymphocyte Activation
Lymphocytes
Medical sciences
Mycoses
Paracoccidioides
Paracoccidioides - immunology
Paracoccidioides brasiliensis
Paracoccidioidomycosis
Paracoccidioidomycosis - immunology
Reference Values
Skin tests
T lymphocytes
T-Lymphocytes - immunology
Tropical medicine
Tropical mycoses
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Summary:To assess human cellular immune response to paracoccidioidomycosis (PCM), lymphocyte proliferative responses to purified antigens from Paracoccidioides brasiliensis were determined in healthy persons previously infected by the fungus (positive donors), in healthy noninfected persons (controls), and in PCM patients. Affinity-purified gp70 and gp43, the two major antigens in humoral immune responses, were used. Both induced lymphocyte proliferation (gp43 species-specific) in positive donors but not in controls; healthy persons previously infected by Histoplasma capsulatum reacted to gp70 and not to gp43. A similar cross-reactivity in antibody response to gp70 was previously reported; however, antibody response to gp43 has been considered specific. Lymphocytes from PCM patients, who, unlike positive donors, have high levels of anti-gp43 and anti-gp70 antibodies, proliferated poorly with gp70 and gp43 but better with other stimuli. This dichotomy between humoral and cellular antigen-specific responses suggests a Th2 immune response in PCM, which may be related to failure to control the infection.
ISSN:0022-1899
1537-6613
DOI:10.1086/593694