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Immunosuppression in Paracoccidioidomycosis: T Cell Hyporesponsiveness to Two Paracoccidioides brasiliensis Glycoproteins that Elicit Strong Humoral Immune Response
To assess human cellular immune response to paracoccidioidomycosis (PCM), lymphocyte proliferative responses to purified antigens from Paracoccidioides brasiliensis were determined in healthy persons previously infected by the fungus (positive donors), in healthy noninfected persons (controls), and...
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| Published in: | The Journal of infectious diseases 1997-05, Vol.175 (5), p.1263-1267 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 1267 |
| container_issue | 5 |
| container_start_page | 1263 |
| container_title | The Journal of infectious diseases |
| container_volume | 175 |
| creator | Benard, Gil Mendes-Giannini, Maria José S. Juvenale, Michelangelo Miranda, Elaine T. Duarte, Alberto J. S. |
| description | To assess human cellular immune response to paracoccidioidomycosis (PCM), lymphocyte proliferative responses to purified antigens from Paracoccidioides brasiliensis were determined in healthy persons previously infected by the fungus (positive donors), in healthy noninfected persons (controls), and in PCM patients. Affinity-purified gp70 and gp43, the two major antigens in humoral immune responses, were used. Both induced lymphocyte proliferation (gp43 species-specific) in positive donors but not in controls; healthy persons previously infected by Histoplasma capsulatum reacted to gp70 and not to gp43. A similar cross-reactivity in antibody response to gp70 was previously reported; however, antibody response to gp43 has been considered specific. Lymphocytes from PCM patients, who, unlike positive donors, have high levels of anti-gp43 and anti-gp70 antibodies, proliferated poorly with gp70 and gp43 but better with other stimuli. This dichotomy between humoral and cellular antigen-specific responses suggests a Th2 immune response in PCM, which may be related to failure to control the infection. |
| doi_str_mv | 10.1086/593694 |
| format | article |
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S.</creator><creatorcontrib>Benard, Gil ; Mendes-Giannini, Maria José S. ; Juvenale, Michelangelo ; Miranda, Elaine T. ; Duarte, Alberto J. S.</creatorcontrib><description>To assess human cellular immune response to paracoccidioidomycosis (PCM), lymphocyte proliferative responses to purified antigens from Paracoccidioides brasiliensis were determined in healthy persons previously infected by the fungus (positive donors), in healthy noninfected persons (controls), and in PCM patients. Affinity-purified gp70 and gp43, the two major antigens in humoral immune responses, were used. Both induced lymphocyte proliferation (gp43 species-specific) in positive donors but not in controls; healthy persons previously infected by Histoplasma capsulatum reacted to gp70 and not to gp43. A similar cross-reactivity in antibody response to gp70 was previously reported; however, antibody response to gp43 has been considered specific. Lymphocytes from PCM patients, who, unlike positive donors, have high levels of anti-gp43 and anti-gp70 antibodies, proliferated poorly with gp70 and gp43 but better with other stimuli. This dichotomy between humoral and cellular antigen-specific responses suggests a Th2 immune response in PCM, which may be related to failure to control the infection.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/593694</identifier><identifier>PMID: 9129101</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Antibody Formation ; Antigens ; Antigens, Fungal - immunology ; Biological and medical sciences ; Blastomycoses and paracoccidioidomycosis ; Cell walls ; Cells, Cultured ; Concise Communications ; Cross reaction ; Fungal infections ; Fungal Proteins - immunology ; Glycoproteins ; Human mycoses ; Humans ; Immune Tolerance ; Immunity, Cellular ; Infectious diseases ; Lymphocyte Activation ; Lymphocytes ; Medical sciences ; Mycoses ; Paracoccidioides ; Paracoccidioides - immunology ; Paracoccidioides brasiliensis ; Paracoccidioidomycosis ; Paracoccidioidomycosis - immunology ; Reference Values ; Skin tests ; T lymphocytes ; T-Lymphocytes - immunology ; Tropical medicine ; Tropical mycoses</subject><ispartof>The Journal of infectious diseases, 1997-05, Vol.175 (5), p.1263-1267</ispartof><rights>Copyright 1997 The University of Chicago</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-3ec8b5156412b19bd144ff64eb411694e672055a1d3bdaa833c839146a553ffc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30132664$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30132664$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,58221,58454</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2663387$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9129101$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Benard, Gil</creatorcontrib><creatorcontrib>Mendes-Giannini, Maria José S.</creatorcontrib><creatorcontrib>Juvenale, Michelangelo</creatorcontrib><creatorcontrib>Miranda, Elaine T.</creatorcontrib><creatorcontrib>Duarte, Alberto J. S.</creatorcontrib><title>Immunosuppression in Paracoccidioidomycosis: T Cell Hyporesponsiveness to Two Paracoccidioides brasiliensis Glycoproteins that Elicit Strong Humoral Immune Response</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>To assess human cellular immune response to paracoccidioidomycosis (PCM), lymphocyte proliferative responses to purified antigens from Paracoccidioides brasiliensis were determined in healthy persons previously infected by the fungus (positive donors), in healthy noninfected persons (controls), and in PCM patients. Affinity-purified gp70 and gp43, the two major antigens in humoral immune responses, were used. Both induced lymphocyte proliferation (gp43 species-specific) in positive donors but not in controls; healthy persons previously infected by Histoplasma capsulatum reacted to gp70 and not to gp43. A similar cross-reactivity in antibody response to gp70 was previously reported; however, antibody response to gp43 has been considered specific. Lymphocytes from PCM patients, who, unlike positive donors, have high levels of anti-gp43 and anti-gp70 antibodies, proliferated poorly with gp70 and gp43 but better with other stimuli. This dichotomy between humoral and cellular antigen-specific responses suggests a Th2 immune response in PCM, which may be related to failure to control the infection.</description><subject>Antibody Formation</subject><subject>Antigens</subject><subject>Antigens, Fungal - immunology</subject><subject>Biological and medical sciences</subject><subject>Blastomycoses and paracoccidioidomycosis</subject><subject>Cell walls</subject><subject>Cells, Cultured</subject><subject>Concise Communications</subject><subject>Cross reaction</subject><subject>Fungal infections</subject><subject>Fungal Proteins - immunology</subject><subject>Glycoproteins</subject><subject>Human mycoses</subject><subject>Humans</subject><subject>Immune Tolerance</subject><subject>Immunity, Cellular</subject><subject>Infectious diseases</subject><subject>Lymphocyte Activation</subject><subject>Lymphocytes</subject><subject>Medical sciences</subject><subject>Mycoses</subject><subject>Paracoccidioides</subject><subject>Paracoccidioides - immunology</subject><subject>Paracoccidioides brasiliensis</subject><subject>Paracoccidioidomycosis</subject><subject>Paracoccidioidomycosis - immunology</subject><subject>Reference Values</subject><subject>Skin tests</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes - immunology</subject><subject>Tropical medicine</subject><subject>Tropical mycoses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFkc1u1DAUhSMEKtMCb4DkBWIX8I1_ErNDo7ZTqaJlGBBiYzmOAy5JHHwTYN6HB8XtjKYSG1ZenO-ce69Plj0D-gpoJV8LxaTiD7IFCFbmUgJ7mC0oLYocKqUeZ8eIN5RSzmR5lB0pKBRQWGR_Lvp-HgLO4xgdog8D8QO5NtHYYK1vfPBN6Lc2oMc3ZEOWruvIajuGRI9hQP_TDclHpkA2v8I_RoekjgZ9510ikZx3KWiMYXJ-SJZvZiKnnbd-Ih-mGIavZDX3IZqO3C3lyHo3wz3JHrWmQ_d0_55kH89ON8tVfnl1frF8e5lbpuSUM2erWoCQHIoaVN0A520ruas5QPocJ8uCCmGgYXVjTMWYrZgCLo0QrG0tO8le7nLTjj9mh5PuPdp0sRlcmFGXleKskuK_IEhacgrVPWhjQIyu1WP0vYlbDVTf9qZ3vSXw-T5xrnvXHLB9UUl_sdcNWtO10QzW4wErpGSsKu9jbnAK8SCzlJCQ2zH5Tvc4ud8H3cTvWpasFHr1-YuGd8v3n_h6ra_ZXzB1u48</recordid><startdate>19970501</startdate><enddate>19970501</enddate><creator>Benard, Gil</creator><creator>Mendes-Giannini, Maria José S.</creator><creator>Juvenale, Michelangelo</creator><creator>Miranda, Elaine T.</creator><creator>Duarte, Alberto J. S.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>19970501</creationdate><title>Immunosuppression in Paracoccidioidomycosis: T Cell Hyporesponsiveness to Two Paracoccidioides brasiliensis Glycoproteins that Elicit Strong Humoral Immune Response</title><author>Benard, Gil ; Mendes-Giannini, Maria José S. ; Juvenale, Michelangelo ; Miranda, Elaine T. ; Duarte, Alberto J. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-3ec8b5156412b19bd144ff64eb411694e672055a1d3bdaa833c839146a553ffc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Antibody Formation</topic><topic>Antigens</topic><topic>Antigens, Fungal - immunology</topic><topic>Biological and medical sciences</topic><topic>Blastomycoses and paracoccidioidomycosis</topic><topic>Cell walls</topic><topic>Cells, Cultured</topic><topic>Concise Communications</topic><topic>Cross reaction</topic><topic>Fungal infections</topic><topic>Fungal Proteins - immunology</topic><topic>Glycoproteins</topic><topic>Human mycoses</topic><topic>Humans</topic><topic>Immune Tolerance</topic><topic>Immunity, Cellular</topic><topic>Infectious diseases</topic><topic>Lymphocyte Activation</topic><topic>Lymphocytes</topic><topic>Medical sciences</topic><topic>Mycoses</topic><topic>Paracoccidioides</topic><topic>Paracoccidioides - immunology</topic><topic>Paracoccidioides brasiliensis</topic><topic>Paracoccidioidomycosis</topic><topic>Paracoccidioidomycosis - immunology</topic><topic>Reference Values</topic><topic>Skin tests</topic><topic>T lymphocytes</topic><topic>T-Lymphocytes - immunology</topic><topic>Tropical medicine</topic><topic>Tropical mycoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Benard, Gil</creatorcontrib><creatorcontrib>Mendes-Giannini, Maria José S.</creatorcontrib><creatorcontrib>Juvenale, Michelangelo</creatorcontrib><creatorcontrib>Miranda, Elaine T.</creatorcontrib><creatorcontrib>Duarte, Alberto J. S.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Benard, Gil</au><au>Mendes-Giannini, Maria José S.</au><au>Juvenale, Michelangelo</au><au>Miranda, Elaine T.</au><au>Duarte, Alberto J. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunosuppression in Paracoccidioidomycosis: T Cell Hyporesponsiveness to Two Paracoccidioides brasiliensis Glycoproteins that Elicit Strong Humoral Immune Response</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1997-05-01</date><risdate>1997</risdate><volume>175</volume><issue>5</issue><spage>1263</spage><epage>1267</epage><pages>1263-1267</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>To assess human cellular immune response to paracoccidioidomycosis (PCM), lymphocyte proliferative responses to purified antigens from Paracoccidioides brasiliensis were determined in healthy persons previously infected by the fungus (positive donors), in healthy noninfected persons (controls), and in PCM patients. Affinity-purified gp70 and gp43, the two major antigens in humoral immune responses, were used. Both induced lymphocyte proliferation (gp43 species-specific) in positive donors but not in controls; healthy persons previously infected by Histoplasma capsulatum reacted to gp70 and not to gp43. A similar cross-reactivity in antibody response to gp70 was previously reported; however, antibody response to gp43 has been considered specific. Lymphocytes from PCM patients, who, unlike positive donors, have high levels of anti-gp43 and anti-gp70 antibodies, proliferated poorly with gp70 and gp43 but better with other stimuli. This dichotomy between humoral and cellular antigen-specific responses suggests a Th2 immune response in PCM, which may be related to failure to control the infection.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>9129101</pmid><doi>10.1086/593694</doi><tpages>5</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 1997-05, Vol.175 (5), p.1263-1267 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78943865 |
| source | JSTOR Archival Journals and Primary Sources Collection; Oxford Journals Online |
| subjects | Antibody Formation Antigens Antigens, Fungal - immunology Biological and medical sciences Blastomycoses and paracoccidioidomycosis Cell walls Cells, Cultured Concise Communications Cross reaction Fungal infections Fungal Proteins - immunology Glycoproteins Human mycoses Humans Immune Tolerance Immunity, Cellular Infectious diseases Lymphocyte Activation Lymphocytes Medical sciences Mycoses Paracoccidioides Paracoccidioides - immunology Paracoccidioides brasiliensis Paracoccidioidomycosis Paracoccidioidomycosis - immunology Reference Values Skin tests T lymphocytes T-Lymphocytes - immunology Tropical medicine Tropical mycoses |
| title | Immunosuppression in Paracoccidioidomycosis: T Cell Hyporesponsiveness to Two Paracoccidioides brasiliensis Glycoproteins that Elicit Strong Humoral Immune Response |
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