Two Major Strains of Type 1 Wild Poliovirus Circulating in Indochina

Two hundred ninety-four isolates from 329 patients with acute flaccid paralysis in Cambodia and Vietnam during 1992-1995 were identified as type 1 wild polioviruses. Among these isolates, 85 were selected as geographic representatives and were examined by determining the nucleotide sequences of thei...

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Bibliographic Details
Published in:The Journal of infectious diseases 1997-05, Vol.175 (5), p.1233-1237
Main Authors: Yoshida, Hiromu, Li, Jie, Yoneyama, Tetsuo, Yoshii, Kumiko, Shimizu, Hiroyuki, Nguyen Thi Hien Thanh, Toda, Kohei, Long, Nguyen Thanh, Tu, Phan Van, Miyamura, Tatsuo, Hagiwara, Akio
Format: Article
Language:English
Subjects:
Antigens, Viral - genetics
Biological and medical sciences
Cambodia
Capsid - genetics
Capsid Proteins
Cell Line
Concise Communications
DNA Primers
Feces - virology
Genome, Viral
Genomes
Genotypes
Geography
Human viral diseases
Humans
Infectious diseases
Medical genetics
Medical sciences
Nucleotide sequences
Phylogeny
Polio
Poliomyelitis
Poliomyelitis - virology
Poliovirus
Poliovirus - classification
Poliovirus - genetics
Poliovirus - isolation & purification
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Tropical medicine
Vietnam
Viral diseases
Viral diseases of the nervous system
Virology
Viruses
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Summary:Two hundred ninety-four isolates from 329 patients with acute flaccid paralysis in Cambodia and Vietnam during 1992-1995 were identified as type 1 wild polioviruses. Among these isolates, 85 were selected as geographic representatives and were examined by determining the nucleotide sequences of their genome in the VP1 region. The phylogenic analysis revealed that all of the isolates examined were classified into groups A and B. Isolates belonging to group A had been found only in northern Vietnam until 1993 but not in 1994 and 1995. Group B isolates were located in both northern and southern Vietnam and Cambodia. In 1994 and 1995, however, only group B isolates were found in the Mekong Delta area in southern Vietnam and Cambodia. Isolates of groups A and B were genetically different from strains previously isolated in other Asian countries. One of the two indigenous wild polioviruses still remains to be eliminated in this area.
ISSN:0022-1899
1537-6613
DOI:10.1086/593677